Biliary neoplasia with extensive intraductal spread associated with liver cirrhosis: a hitherto unreported variant of biliary intraepithelial neoplasia

Human Pathology
Shinichi AishimaMasazumi Tsuneyoshi

Abstract

We describe the histopathologic features of 2 cases of biliary neoplasia with extensive intraductal spread arising in liver cirrhosis. The prevalence of this type of biliary neoplasia may be 0.4% from the review of 468 cases of cirrhotic liver. Histologic analysis revealed that the micropapillary proliferation of the atypical biliary epithelium composed of columnar cells with enlarged nuclei diffusely extended superficially from the septal intrahepatic bile duct to the reactive ductules associated with liver cirrhosis. Both cases exhibited prominent fibrous or sclerotic stroma near the biliary lesion. Immunohistochemical analysis revealed a characteristic cytokeratin and mucin expression pattern (CK7++, CK19++, CK20+, MUC1+/-, MUC2-, MUC5AC+, MUC6-). The tumor cytoplasm was focally positive for laminin gamma2 together with linear staining of the basement membrane. Proliferative activity confirmed by Ki67 staining was relatively high. Both patients were disease-free for 3 years after the operation. We believe that the possibility of biliary neoplasia with extensive intraductal spread should be considered to be a variant of biliary intraepithelial neoplasia.

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Citations

May 12, 2009·Medical Hypotheses·Yixin LinNansheng Cheng
Jan 22, 2014·Journal of Hepato-biliary-pancreatic Sciences·Shinichi AishimaYoshinao Oda
Apr 30, 2010·Virchows Archiv : an International Journal of Pathology·Anne-Laure RougemontLaura Rubbia-Brandt
Apr 26, 2013·Journal of Gastroenterology·Yasunori SatoUNKNOWN Hepatolithiasis Subdivision of Intractable Hepatobiliary Diseases Study Group of Japan (Chairman, Hirohito Tsubouchi)
Nov 23, 2019·Archives of Pathology & Laboratory Medicine·Sun-Young JunSeung-Mo Hong
Mar 1, 2013·Virchows Archiv : an International Journal of Pathology·Yasunori SatoYasuni Nakanuma
Nov 12, 2015·World Journal of Hepatology·Mark EttelRuliang Xu
Jul 1, 2020·Clinical Pathology·Bita Geramizadeh
Aug 3, 2019·Japanese Journal of Radiology·Mami HamaokaSatoshi Kobayashi

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