Biliary Neuroendocrine Neoplasms: Clinical Profiles, Management, and Analysis of Prognostic Factors

Frontiers in Oncology
Zhibo ZhengYu-Pei Zhao

Abstract

Biliary neuroendocrine neoplasms (NENs) represent <1% of all NENs. The aim of this retrospective study is to present the clinical characteristics, management and prognosis profiles of 28 biliary NEN patients from a large tertiary center, and identify factors related to prognosis. Nine tumors originated from the gallbladder, two from the extrahepatic bile duct and 17 from the ampulla of Vater. One patient was classified as neuroendocrine tumor (NET) Grade 1, three patients were classified as NET Grade 2, 18 were graded neuroendocrine carcinoma (NEC) Grade 3 and six were classified as mixed adenoneuroendocrine carcinoma (MANEC). The overall survival rate and disease-free survival rate did not have statistically significant differences between tumors of different locations or different grading. Recurrence of disease correlated with poor prognosis (p < 0.001). Lymphovascular invasion and invasion beyond the submucosa were related to higher risk of local lymph node metastases. Multivariate analysis identified patient age (p = 0.021) and R0 resection margin (p = 0.027) as independent prognostic factors associated with overall survival. Our study included relatively large numbers of biliary tract NENs with intact follow-up information...Continue Reading

References

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Citations

Jan 23, 2020·Journal of Clinical Medicine·Melissa FrizzieroMairéad G McNamara
Jul 8, 2020·Surgical Case Reports·Takashi MaedaHiroyuki Matsuda
Jun 28, 2020·Surgical Case Reports·Hiroharu ItoHideki Saitsu
Feb 28, 2020·World Journal of Gastroenterology : WJG·Ming JinSheng Yan

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Methods Mentioned

BETA
biopsy
surgical resection

Software Mentioned

SPSS
GraphPad Prism

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