Biliopancreatic limb plays an important role in metabolic improvement after duodenal-jejunal bypass in a rat model of diabetes

Surgery
Tomohiro MiyachiMichiaki Unno

Abstract

Roux-en-Y gastric bypass improves glucose metabolism in clinical practice, and duodenal-jejunal bypass (DJB), an experimental bypass procedure, also improves metabolism in animals. However, the mechanism remains controversial; especially, the role of the biliopancreatic limb (BP-limb) remains unclear. Our aim was to examine the importance of the function of the BP-limb after DJB using a novel operative model. Otsuka Long-Evans Tokushima Fatty rats with diabetes were divided into the following groups: DJB with a short alimentary limb (A-limb) and long BP-limb (B-DJB group), DJB with jejunectomy (J-DJB group) in which the entire length of the jejunum used for the BP-limb of the B-DJB group was excised; and a sham operation group. Glucose tolerance, plasma bile acid levels, and the gut microbiota were assessed postoperatively. Glucose tolerance was improved and weight gain was suppressed after surgery in the B-DJB group. In contrast, these effects were cancelled in the J-DJB group. The plasma levels of bile acids in the B-DJB group were greater than those in other groups. The analysis of gut microbiota showed distinct differences between the B-DJB and other groups; especially, the relative abundance of genus Bifidobacterium was mu...Continue Reading

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Citations

Sep 17, 2017·European Journal of Endocrinology·Yan GuoDa-Jin Zou
Nov 4, 2016·Nature Reviews. Gastroenterology & Hepatology·Kristina Guyton, John C Alverdy
Nov 4, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·A PalA Tavakkoli
May 26, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Bárbara G PatrícioMariana P Monteiro
May 16, 2019·Journal of Obesity & Metabolic Syndrome·Young Suk ParkHyung-Ho Kim
Apr 20, 2019·Frontiers in Physiology·Wenting WangSanyuan Hu
Jan 26, 2021·American Journal of Physiology. Endocrinology and Metabolism·Camille MarciniakFrançois Pattou
Feb 24, 2021·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Meshari AlmuhannaYi-Chih Lee

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