Bilirubin and oxidative stress in term and preterm infants

Free Radical Research
Carlo DaniSimone Pratesi

Abstract

Hyperbilirubinemia is the most frequent clinical problem neonatologists must deal with during the newborn period. It has been suggested that bilirubin is involved in the balance between antioxidant and pro-oxidant agents due to its antioxidant properties. However, the relevance of these effects in vivo in term and preterm infants is still debated. We performed a literature review of studies that investigated the association between total serum bilirubin (TSB) and oxidative stress in newborn infants. We found that studies in term infants give contradictory results, while studies in preterm infants suggest that the TSB increase is associated with an oxidative stress increase due to concurrent factors other than bilirubin level, such as heme oxygenase (HO) activity. Moreover, it could be speculated that low physiologic TSB values are associated with antioxidant effects, while high pathologic TSB values are associated with pro-oxidant effects. Literature data do not allow the establishment of whether if the antioxidant properties of bilirubin are important from a clinical point of view and can affect the outcome in ill infants.

References

Oct 1, 1991·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·T W WuD Carey
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R StockerB N Ames
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R Stocker, B N Ames
Apr 1, 1982·Biochemical Society Transactions·J M Gutteridge
Oct 1, 1995·Free Radical Biology & Medicine·P A DenneryD K Stevenson
Aug 1, 1994·FEBS Letters·V GopinathanC A Rice-Evans
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·G F VileR M Tyrrell
Jun 1, 1996·American Journal of Respiratory Cell and Molecular Biology·P J LeeA M Choi
Jan 1, 1997·Biology of the Neonate·S BélangerP Chessex
Apr 16, 1998·The Journal of Clinical Investigation·P A DenneryK D Poss
Apr 30, 1998·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M G Di BelloP F Mannaioni
Mar 24, 1999·Pediatric Research·L C MirelesP A Dennery
Apr 22, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·S YiğitG Tekinalp
May 4, 1999·International Archives of Allergy and Immunology·C MirabellaP F Mannaioni
Nov 13, 1999·Nature Cell Biology·C D FerrisS H Snyder
Jun 8, 2000·Current Topics in Cellular Regulation·P A Dennery
Oct 21, 2000·American Journal of Perinatology·D W Thibeault
Sep 5, 2001·Pediatrics·UNKNOWN AAP Subcommittee on Neonatal Hyperbilirubinemia
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·F TamionC Thuillez
Aug 10, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Abdoulaye SambJorge Boczkowski
Feb 25, 2003·Archives of Disease in Childhood. Fetal and Neonatal Edition·C DaniF F Rubaltelli
Jul 3, 2004·Pediatrics·UNKNOWN American Academy of Pediatrics Subcommittee on Hyperbilirubinemia
Jul 27, 2004·Pediatric Pulmonology·Carlo DaniFirmino F Rubaltelli
Oct 8, 2004·Pediatric Research·Carlo DaniFirmino F Rubaltelli
Dec 13, 2006·Journal of Tropical Pediatrics·Ashok KumarH D Khanna
Mar 12, 2011·Human & Experimental Toxicology·Murat DoğanOguz Tuncer
Mar 29, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·S BasuA Kumar

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Citations

Feb 1, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jin-Fu ZhouXiao-Long Qiu
Sep 8, 2019·Pediatric Research·Giulia Bortolussi, Andrés F Muro
May 16, 2019·Pediatric Research·Sigrid HahnMonika Berns
Nov 24, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Rona AkefiAmir Almasi-Hashiani
May 8, 2021·Frontiers in Pediatrics·Carlo DaniElisabetta Gerace
Jan 7, 2022·Journal of Enzyme Inhibition and Medicinal Chemistry·Alessio NocentiniClaudiu T Supuran

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