Bilirubin and serial auditory brainstem responses in premature infants

Pediatrics
Sanjiv B AminRonnie Guillet

Abstract

To determine the usefulness of the bilirubin-albumin (B:A) molar ratio (MR) and unbound bilirubin (UB) as compared with serum total bilirubin (TB) in predicting bilirubin encephalopathy as assessed by auditory brainstem responses (ABR) in infants of 28 to 32 weeks' gestational age. During a 2-year period, serial ABRs were obtained on 143 infants of 28 to 32 weeks' gestational age during the first postnatal week. Waveforms were categorized on the basis of response replicability and the presence of waves III and V. Wave V latencies were also serially analyzed when measurable for individual infants. Maturation of the ABR was defined as abnormal when the waveform category worsened and/or latency increased during the study interval. Serum albumin was analyzed at 48 to 72 hours of age in all patients. Serum TB was analyzed as clinically indicated. Aliquots of the same samples were also analyzed for UB in a subset of infants. The mean peak TB concentration (10.1 +/- 1.7 mg/dL) for the 71 infants with normal ABR maturation was not significantly different from the mean peak TB (10.2 +/- 2.1 mg/dL) in the 24-hour period preceding the ABR's first showing abnormal maturation in the other 55 infants. However, in infants with UB analyzed, th...Continue Reading

Associated Clinical Trials

Citations

Oct 20, 2011·Journal of Autism and Developmental Disorders·Sanjiv B AminHongyue Wang
Dec 20, 2003·Pediatric Neurology·Steven M Shapiro
Jun 7, 2003·International Journal of Pediatric Otorhinolaryngology·Isabelle Rapin, Judith Gravel
Feb 4, 2010·Current Opinion in Pediatrics·Charles E Ahlfors
Nov 7, 2003·Archives of Disease in Childhood. Fetal and Neonatal Edition·M J Maisels, J F Watchko
Jul 16, 2010·JPEN. Journal of Parenteral and Enteral Nutrition·Sanjiv B Amin
Nov 25, 2005·Pediatric Research·Charles E Ahlfors, Anne E Parker
Jan 2, 2009·Pediatrics·Sanjiv B AminGary Myers
Dec 7, 2013·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Ze D JiangCao Chen
Sep 23, 2014·Seminars in Perinatology·Sanjiv B AminJon F Watchko
Oct 12, 2014·Seminars in Perinatology·Christian V Hulzebos, Peter H Dijk
Dec 5, 2012·Japanese Journal of Radiology·Hasan CeceOmer Karakas
Apr 22, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·Sanjiv B AminRonnie Guillet
Apr 2, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·M KaplanD K Stevenson
Feb 27, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·C E AhlforsA E Parker
Jan 9, 2009·European Journal of Pediatrics·Ze Dong JiangAndrew Robert Wilkinson
May 29, 2016·Clinics in Perinatology·Cristen Olds, John S Oghalai
Apr 17, 2013·Brain & Development·Ze D Jiang, Andrew R Wilkinson
Jun 7, 2011·Seminars in Perinatology·Sanjiv B Amin, Angelo A Lamola
Jan 12, 2010·Seminars in Fetal & Neonatal Medicine·Jon F Watchko, M Jeffrey Maisels
Dec 7, 2007·International Journal of Pediatric Otorhinolaryngology·Gabriela RomeroCarlos Torner
Jul 14, 2007·Pediatric Neurology·Ze Dong JiangAndrew Robert Wilkinson
Jun 13, 2006·Clinics in Perinatology·Steven M ShapiroLois Johnson
Apr 3, 2012·Pediatrics International : Official Journal of the Japan Pediatric Society·Servet OzkirazAylin Tarcan
Sep 18, 2012·Pediatrics International : Official Journal of the Japan Pediatric Society·Tomoyuki YokotaKazumoto Iijima
May 8, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Yong-Kye LeeHirokuni Negishi
Feb 3, 2005·Seminars in Perinatology·Vinod K BhutaniSteven M Shapiro
Feb 3, 2005·Seminars in Perinatology·Charles E Ahlfors, Richard P Wennberg
Feb 3, 2005·Seminars in Perinatology·Sanjiv B Amin
May 29, 2016·Clinics in Perinatology·Vinod K BhutaniDavid K Stevenson
Oct 4, 2006·Seminars in Fetal & Neonatal Medicine·Andrew R Wilkinson, Ze D Jiang
Oct 31, 2006·Clinical Biochemistry·Charles E AhlforsUNKNOWN National Institute of Child Health and Development (NICHD) Neonatal Research Network
Sep 20, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Charles E AhlforsBart Van Overmeire
Jan 9, 2003·Clinics in Perinatology·Jeffrey M Perlman
Jun 7, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Michael Kaplan, Cathy Hammerman
May 29, 2016·Clinics in Perinatology·Sanjiv B Amin
May 7, 2013·International Journal of Pediatric Otorhinolaryngology·Olubunmi Victoria AkinpeluSam J Daniel
Jan 19, 2015·The Journal of Pediatrics·Sanjiv B Amin, Hongyue Wang

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