Bilirubin inhibits iNOS expression and NO production in response to endotoxin in rats

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Weizheng W WangStephen D Zucker

Abstract

The inducible isoform of heme oxygenase (HO), HO-1, has been shown to play an important role in attenuating tissue injury. Because HO-1 catalyzes the rate-limiting step in bilirubin synthesis, we examined the hypothesis that bilirubin is a key mediator of HO-1 cytoprotection, employing a rat model of endotoxemia. Bilirubin treatment resulted in improved survival and attenuated liver injury in response to lipopolysaccharide infusion. Serum levels of NO and tumor necrosis factor alpha, key mediators of endotoxemia, and hepatic inducible nitric oxide synthase (iNOS) expression were significantly lower in bilirubin-treated rodents versus control animals. Both intraperitoneal and local administration of bilirubin also was found to ameliorate hindpaw inflammation induced by the injection of lambda-carrageenan. Consistent with in vivo results, bilirubin significantly inhibited iNOS expression and suppressed NO production in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophages. In contrast, bilirubin treatment induced a threefold increase in LPS-mediated prostaglandin synthesis in the absence of significant changes in cyclooxygenase expression or activity, suggesting that bilirubin enhances substrate availability for eicosa...Continue Reading

References

Jan 1, 1979·Gut·T A Miller, E D Jacobson
Sep 1, 1972·The Biochemical Journal·A F McDonagh, F Assisi
Jan 1, 1982·Methods in Enzymology·J A Salmon, R J Flower
Mar 30, 1994·Biochemical and Biophysical Research Communications·I M AdcockP J Barnes
Nov 2, 1995·The New England Journal of Medicine·P J BosmaR P Oude Elferink
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D SalveminiP Needleman
Jan 1, 1996·Nature Medicine·D WillisD A Willoughby
Jun 1, 1996·British Journal of Pharmacology·D SalveminiM G Currie
Apr 10, 1997·The New England Journal of Medicine·P J Barnes, M Karin
Feb 1, 1997·The American Journal of Physiology·L OtterbeinA M Choi
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·M D Maines
Jul 22, 1998·European Journal of Pharmacology·R ZamoraA G Herman
Aug 12, 1999·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·R PatelA R Amin
Nov 13, 1999·Nature Cell Biology·C D FerrisS H Snyder
Dec 10, 1999·The Journal of Clinical Investigation·F AmersiJ W Kupiec-Weglinski
Feb 17, 2000·Biochimica Et Biophysica Acta·S D Zucker, W Goessling
Jun 2, 2001·Journal of Photochemistry and Photobiology. B, Biology·A I NovairaC M Previtali
Jul 12, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·W P WangC H Cho
Sep 29, 2001·Nature Immunology·C Bogdan
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·S D ZuckerK E Sherman
Oct 27, 2001·Acta Physiologica Scandinavica·F S LarouxM B Grisham
Dec 18, 2001·Pharmacology & Therapeutics·F FeihlL Liaudet
Mar 21, 2002·The Lancet Oncology·P K Lala, C Chakraborty
May 15, 2002·Antioxidants & Redox Signaling·Leo E Otterbein
Nov 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·David E BarananoSolomon H Snyder
Mar 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wendong HuangDavid D Moore

❮ Previous
Next ❯

Citations

Apr 25, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Miyoko MatsushimaTsutomu Kawabe
Jun 22, 2011·Rheumatology International·Zaixing YangRenqian Zhong
May 4, 2012·Archives of Pharmacal Research·Jin-Ah LeeHyeun Kyoo Shin
Jun 14, 2005·Trends in Molecular Medicine·Igino RigatoClaudio Tiribelli
Feb 18, 2012·Journal of Agricultural and Food Chemistry·Shanshan GuoHang Xiao
Oct 9, 2007·Antioxidants & Redox Signaling·Robert OllingerFritz H Bach
Jun 26, 2008·Antioxidants & Redox Signaling·Agnieszka LobodaJozef Dulak
Jun 1, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Ryujiro SugimotoAtsunori Nakao
May 29, 2009·Clinical and Experimental Pharmacology & Physiology·Xiao-Dong FangYing-Ying Chen
Nov 28, 2012·Neonatology·Barry WeinbergerThomas Hegyi
Aug 16, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Sungsoo LeeAtsunori Nakao
Jul 9, 2010·Fukushima Journal of Medical Science·Hiroyuki KuniiYukio Maruyama
Jul 11, 2008·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Dietmar TamandlPeter Goetzinger
Nov 1, 2005·Expert Opinion on Investigational Drugs·Roberto MotterliniRoberta Foresti
Aug 6, 2014·International Immunopharmacology·Yunsoo ParkSang-Bae Han
Nov 22, 2011·Prostaglandins & Other Lipid Mediators·Angela BurgessNader G Abraham
May 6, 2011·Early Human Development·Paul van den BroekChristian V Hulzebos
Feb 18, 2011·The Journal of Surgical Research·Ching-Wen KungMao-Hsiung Yen
Oct 4, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Geeta NegiShyam S Sharma
Jan 22, 2008·The Journal of Urology·Yoh MatsuokaKazunori Kihara
Sep 24, 2015·Intensive Care Medicine·Marc JenniskensGreet Van den Berghe
Jun 3, 2009·Diabetes/metabolism Research and Reviews·F AstortC B Cymeryng
Mar 10, 2007·Journal of Neuroscience Research·Myung-Soon YangEunhye Joe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.