PMID: 11345177May 10, 2001Paper

Bilirubin-IXbeta is a marker of meconium, like zinc coproporphyrin

Journal of Pediatric Gastroenterology and Nutrition
S AzizJ Fevery

Abstract

Because meconium accumulates continuously in the fetal intestine, analysis of the postnatally excreted material could yield important information of intrauterine metabolism and maturation. Therefore, a study of the bilirubin pigments in meconium and in the first neonatal stools was carried out. Meconium and stools from 37 neonates of various gestational ages were collected carefully, and stored at -20 degrees C, protected by aluminium foil. Samples were defrosted, vortex mixed with an equal amount of dimethyl sulfoxide, centrifuged, and submitted to analysis by high-pressure liquid chromatography using newly developed methods to identify and to quantitate the bilirubin-IXalpha, -IXbeta, -IXgamma, and -IXdelta isomers. In addition, samples were also submitted to diazo coupling with ethyl anthranilate. Total coproporphyrins and zinc coproporphyrin were assayed for comparison. Unconjugated bilirubin-IXalpha and -IXbeta were detected in meconium but not the -IXgamma or the -IXbeta isomer. Bilirubin-IXbeta was the predominant pigment and comprised 63% to 96% of the unconjugated bilirubins in the first sample of meconium excreted. Its amount decreased rapidly during the first 5 days in full-term newborns, but this occurred more slowl...Continue Reading

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Citations

Dec 1, 2006·Fetal Diagnosis and Therapy·Barbara Lisowska-Myjak, Jan Pachecka
Feb 23, 2020·Frontiers in Immunology·Giacomo CanesinBarbara Wegiel
Jul 6, 2021·Free Radical Biology & Medicine·Cesare Mancuso

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