Bilirubin Levels and Thrombus Burden in Patients With ST-Segment Elevation Myocardial Infarction

Angiology
Hikmet HamurHusnu Degirmenci

Abstract

We investigated whether serum bilirubin level (a marker of heme oxygenase activity) is a predictor of thrombus burden in patients with acute myocardial infarction. Patients (n = 229; male 72.9%; mean age 63 ± 13.4 years) who were admitted with ST-segment elevation myocardial infarction (STEMI) were enrolled. Patients were divided into 2 groups. Group 1 was defined as low thrombus burden and group 2 was defined as high thrombus burden. Patients with high thrombus burden had higher total bilirubin levels (14.4 [4.3-22.9] vs 7.7 [2.4-20.3] µmol/L, P ≤ .001), (0.84 [0.25-1.34] vs 0.45 [0.14-1.19] mg/dL P ≤ .001) and direct bilirubin levels (3.1 [2.1-8.4] vs 1.7 [0.5-6.5] µmol/L, P ≤ .001), (0.18 [0.03-0.49] vs 0.10 [0.03-0.38] mg/dL, P ≤ .001). At multivariate analysis, total bilirubin (odds ratio: 1.05, 95% confidence interval: 1.03-1.08, P ≤ .001) was the independent predictor of high thrombus burden. In conclusion, total bilirubin level is independently associated with high thrombus burden in patients with STEMI.

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Citations

Feb 29, 2016·Journal of Diabetes and Its Complications·Lars H Breimer, Dimitri P Mikhailidis
Aug 19, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Arif ArısoyÇağrı Zorlu
Nov 13, 2018·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Junhua GeBo Hou
Sep 10, 2019·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Chaudry N MajeedElsayed Z Soliman
Feb 1, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Karl A NathGregory M Vercellotti
Apr 3, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Gian Luca SalvagnoGiuseppe Lippi
Mar 31, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Andrew C BulmerJohn P Headrick
Feb 28, 2019·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Hakan DumanNadir Emlek

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