Bilirubin nanomedicine alleviates psoriatic skin inflammation by reducing oxidative stress and suppressing pathogenic signaling.

Journal of Controlled Release : Official Journal of the Controlled Release Society
Hyeongseop KeumSangyong Jon

Abstract

Psoriasis is a prevalent chronic inflammatory skin disease characterized by thickening of the epidermis accompanied by lesional erythema, scaling, and induration as a result of abnormal proliferation of keratinocytes. During the development of psoriasis, levels of intracellular reactive oxygen species (ROS) within psoriatic lesions are elevated, activating a pro-inflammatory signaling cascade. Here, we evaluated the therapeutic efficacy and mode of action of bilirubin nanoparticles (BRNPs), based on the potent, endogenous antioxidant bilirubin, in a preclinical psoriasis model. We found that topical treatment of psoriatic lesions with BRNPs effectively attenuated upregulation of intracellular ROS levels within keratinocytes and ameliorated the symptoms of psoriasis. A subsequent mechanistic study showed that preventing oxidative stress in activated keratinocytes suppressed the secretion of inflammatory mediators and recruitment of immune cells. Subsequent expression of the antigen-presenting cell (APC) maturation markers, class II major histocompatibility complex (MHC class II), cluster of differentiation (CD) 80 and CD86, was significantly decreased, resulting in a reduction in the differentiation of naïve CD4+ T cells into in...Continue Reading

References

Apr 1, 1993·Carcinogenesis·R E Mitchel, R McCann
Nov 3, 1998·The British Journal of Ophthalmology·R M Stanbury, E M Graham
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Donald J DavidsonDavid P Speert
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andreas ElssnerMark D Wewers
Oct 26, 2005·Cell Death and Differentiation·S LippensW Declercq
Feb 23, 2007·Nature·Michelle A LowesJames G Krueger
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ilona KryczekWeiping Zou
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leslie van der FitsErik Lubberts
Jul 7, 2009·Free Radical Biology & Medicine·Qiang ZhouMartin Rostami-Yazdi
Jul 31, 2009·The New England Journal of Medicine·Frank O NestleJonathan Barker
Aug 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wendy A GoodmanKevin D Cooper
May 25, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew M LinAllen T Bruce
Jul 21, 2011·European Journal of Immunology·Nicholas W KinJohn F Kearney
Aug 3, 2011·Journal of Leukocyte Biology·Nazir M Khan, T B Poduval
Sep 13, 2012·Frontiers in Immunology·Susanne V SchmidtJoachim L Schultze
Jan 8, 2013·Trends in Immunology·Michelle A LowesJames G Krueger
Sep 3, 2013·Antioxidants & Redox Signaling·Manish MittalAsrar B Malik
Mar 25, 2014·Annual Review of Immunology·Michelle A LowesJames G Krueger
Aug 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ia KhmaladzeRikard Holmdahl
Dec 4, 2014·Nature Communications·Roberto LandeLoredana Frasca
Jan 15, 2015·Cytokine·Jaymie BaliwagAndrew Johnston
Apr 12, 2016·Journal of Clinical Laboratory Analysis·Zhen-Xing ZhouTian-Cheng Wang
Apr 22, 2016·Free Radical Research·Xiran Lin, Tian Huang
May 5, 2016·Angewandte Chemie·Yonghyun LeeSangyong Jon
Aug 4, 2016·Angewandte Chemie·Yonghyun LeeSangyong Jon
Nov 25, 2016·Nature Reviews. Disease Primers·Jacqueline E GrebAlice B Gottlieb
Apr 12, 2017·Frontiers in Immunology·Jacques C MbongueWilliam H R Langridge
Jul 3, 2018·Frontiers in Immunology·Michael P Schön, Luise Erpenbeck
Nov 18, 2018·Nature Immunology·Teruki DainichiKenji Kabashima
Mar 27, 2019·International Journal of Molecular Sciences·Adriana Rendon, Knut Schäkel

❮ Previous
Next ❯

Citations

Jan 16, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tae Woo KimSangyong Jon
Mar 1, 2021·Medical Hypotheses·Isha KhuranaKala Kumar Bharani
Apr 17, 2021·Drug Delivery and Translational Research·Zhengyu Deng, Shiyong Liu
Apr 20, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhiyuan Zhong
May 20, 2021·Biomaterials·Nadim AhamadRinti Banerjee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.