Biliverdin reductase and bilirubin in hepatic disease

American Journal of Physiology. Gastrointestinal and Liver Physiology
Lauren WeaverTerry D Hinds

Abstract

The buildup of fat in the liver (hepatic steatosis) is the first step in a series of incidents that may drive hepatic disease. Obesity is the leading cause of nonalcoholic fatty liver disease (NAFLD), in which hepatic steatosis progresses to liver disease. Chronic alcohol exposure also induces fat accumulation in the liver and shares numerous similarities to obesity-induced NAFLD. Regardless of whether hepatic steatosis is due to obesity or long-term alcohol use, it still may lead to hepatic fibrosis, cirrhosis, or possibly hepatocellular carcinoma. The antioxidant bilirubin and the enzyme that generates it, biliverdin reductase A (BVRA), are components of the heme catabolic pathway that have been shown to reduce hepatic steatosis. This review discusses the roles for bilirubin and BVRA in the prevention of steatosis, their functions in the later stages of liver disease, and their potential therapeutic application.

References

Apr 1, 1989·Baillière's Clinical Gastroenterology·J FeveryN Blanckaert
Jan 1, 1987·Molecular Aspects of Medicine·J FeveryN Blanckaert
Mar 15, 1980·The Biochemical Journal·S G BlumenthalF W Hanson
Jan 1, 1996·Nature Medicine·D WillisD A Willoughby
Feb 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·P N HopkinsR R Williams
Sep 13, 2001·Molecular Biology of the Cell·B HinzC Chaponnier
Feb 19, 2002·The International Journal of Biochemistry & Cell Biology·María L Tomaro, Alcira M del C Batlle
Nov 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·David E BarananoSolomon H Snyder
May 1, 1959·The Journal of Clinical Investigation·G B ODELL
Jun 3, 2004·Pediatrics·Thomas W Sedlak, Solomon H Snyder
Oct 23, 2004·Pharmaceutical Research·Daniel H van RaalteKishor M Wasan
Feb 4, 2005·The Journal of Clinical Investigation·Ramón Bataller, David A Brenner
Oct 29, 2005·Endocrinology·Hongjun WangFritz H Bach
Apr 14, 2006·Journal of Neuroscience Research·Ana C GordoDora Brites
Sep 16, 2006·Biological Chemistry·Jennifer J SchlezingerDavid H Sherr
Jun 15, 2007·Biochimica Et Biophysica Acta·Katherine A Burns, John P Vanden Heuvel
Oct 24, 2007·Nature Medicine·Ekihiro SekiRobert F Schwabe
Dec 13, 2007·Cell Cycle·Robert OllingerRaimund Margreiter
Mar 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Thomas W SedlakSolomon H Snyder
Jul 3, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Trinity VeraDavid E Stec
Jun 1, 2008·Hepatology International·Payal BhardwajAnoop Saraya
Nov 17, 2009·QJM : Monthly Journal of the Association of Physicians·J K DowmanP N Newsome
Nov 20, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Douwe DekkerPaul Smits
Nov 26, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matthew C LoftspringJoseph F Clark
Jan 18, 2011·Journal of Hepatology·Hartmut Jaeschke, Anup Ramachandran
Jun 16, 2011·Journal of Women's Health·Kyung-Min KwonHee-Taik Kang
Nov 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Barbara WegielLeo E Otterbein

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Citations

Apr 11, 2018·American Journal of Physiology. Renal Physiology·Samuel O AdeosunDavid E Stec
Apr 7, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kavita BishtBarbara Wegiel
Oct 11, 2019·Current Hypertension Reports·Terry D Hinds, David E Stec
Sep 5, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David E StecTerry D Hinds
Feb 23, 2020·Frontiers in Immunology·Giacomo CanesinBarbara Wegiel
Oct 26, 2018·Hypertension·Terry D Hinds, David E Stec
Oct 30, 2020·Frontiers in Cellular and Infection Microbiology·Guoqiang SunYao Cheng
Dec 3, 2020·International Journal of Molecular Sciences·Valentina CeccarelliMaria Gisella Cavallo
Dec 8, 2020·American Journal of Physiology. Endocrinology and Metabolism·Justin F CreedenTerry D Hinds
Aug 20, 2019·Archives of Biochemistry and Biophysics·George S DrummondNader G Abraham
Dec 18, 2020·International Journal of Molecular Sciences·David E Stec, Terry D Hinds
Apr 29, 2021·Antioxidants & Redox Signaling·Libor Vítek
Jun 22, 2021·Journal of Hepatology·Libor Vítek, Claudio Tiribelli
Jul 6, 2021·Free Radical Biology & Medicine·Cesare Mancuso

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Methods Mentioned

BETA
biopsies

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