Bilophila wadsworthia aggravates high fat diet induced metabolic dysfunctions in mice

Nature Communications
J N NatividadHarry Sokol

Abstract

Dietary lipids favor the growth of the pathobiont Bilophila wadsworthia, but the relevance of this expansion in metabolic syndrome pathogenesis is poorly understood. Here, we showed that B. wadsworthia synergizes with high fat diet (HFD) to promote higher inflammation, intestinal barrier dysfunction and bile acid dysmetabolism, leading to higher glucose dysmetabolism and hepatic steatosis. Host-microbiota transcriptomics analysis reveal pathways, particularly butanoate metabolism, which may underlie the metabolic effects mediated by B. wadsworthia. Pharmacological suppression of B. wadsworthia-associated inflammation demonstrate the bacterium's intrinsic capacity to induce a negative impact on glycemic control and hepatic function. Administration of the probiotic Lactobacillus rhamnosus CNCM I-3690 limits B. wadsworthia-induced immune and metabolic impairment by limiting its expansion, reducing inflammation and reinforcing intestinal barrier. Our results suggest a new avenue for interventions against western diet-driven inflammatory and metabolic diseases.

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Dec 6, 2018·Physiological Reports·Guadalupe NavarroBrian T Layden
Sep 4, 2019·Annual Review of Medicine·Ilias AttayeMax Nieuwdorp
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Datasets Mentioned

BETA
PRJEB25364
GSE111451
GSE112387

Methods Mentioned

BETA
RNAseq
dissect
ELISA
Protein Assay
chips
Feature Extraction

Software Mentioned

Agilent Feature Extraction
GOstats
R package “ edgeR ”
ImageJ
FastTree
Anosim
Pathway Level Analysis of Gene Expression ( PLAGE
QIIME
GSVA R package )
PLAGE

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