Bimanual coordination dysfunction in early, untreated Parkinson's disease

Parkinsonism & Related Disorders
Mirthe M PonsenHenk W Berendse

Abstract

Bimanual coordination involves the simultaneous performance of either symmetrical (in-phase) or asymmetrical (anti-phase) movements with both hands and is known to be impaired in Parkinson's disease (PD). At present, it is unclear whether this aspect of motor function is already impaired in early stage, untreated PD patients. Therefore, we investigated the accuracy of bimanual coordination in 13 early stage, untreated PD patients and 13 age- and sex-matched healthy controls. Each subject performed bimanual coordination tasks at two different movement frequencies (1 and 1.75 Hz) and with two different phase relationships (in-phase and anti-phase). The percentage of unsuccessful trials (as a measure of overall task performance) in PD patients was significantly higher than in healthy subjects. PD patients performed high frequency in-phase and anti-phase bimanual coordination tasks less accurately with their non-dominant hand than healthy subjects. Furthermore, PD patients had more difficulty than healthy subjects in maintaining a constant phase relationship between the hands in the anti-phase condition at low movement frequency. This study demonstrates that bimanual coordination dysfunction is a very early sign of PD. Bimanual coo...Continue Reading

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Citations

Jun 23, 2010·Brain : a Journal of Neurology·Tao WuPiu Chan
Dec 21, 2010·Human Movement Science·Shannon D R RingenbachGeorge E Stelmach
Apr 29, 2010·Magnetic Resonance Imaging·Marta MoraschiBruno Maraviglia
Oct 5, 2007·Parkinsonism & Related Disorders·Mirthe M PonsenHenk W Berendse
Oct 3, 2007·Archives of Physical Medicine and Rehabilitation·Geert VerheydenAlice Nieuwboer
Mar 25, 2009·The European Journal of Neuroscience·Alice NieuwboerStephan Swinnen
Mar 10, 2015·Neuroscience Research·Jean-François DaneaultChristian Duval
Mar 26, 2015·Behavioural Brain Research·Griet VervoortAlice Nieuwboer
Dec 17, 2014·Frontiers in Human Neuroscience·A R E PotgieserR J M Groen
Jan 13, 2015·Journal of Motor Behavior·Hayley J MacDonald, Winston D Byblow
Nov 8, 2018·Journal of Neurophysiology·Masakazu Igarashi, Jeff Wickens
Mar 14, 2019·International Journal of Environmental Research and Public Health·Jarosław MarusiakArtur Jaskólski
Jun 26, 2020·Frontiers in Neuroscience·Jacky GangulyMandar Jog
Feb 18, 2017·Scientific Reports·Ariel TankusJeffrey M Hausdorff
Jun 25, 2010·Neurology·G K KerrP A Silburn

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