Bimatoprost: a pharmacoeconomic review of its use in open-angle glaucoma and ocular hypertension

PharmacoEconomics
Greg L Plosker, Susan J Keam

Abstract

Bimatoprost (Lumigan) is a prostamide analogue used for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. In comparative clinical trials of up to 1 year in duration, administration of 0.03% bimatoprost ophthalmic solution once daily was more effective than 0.5% timolol twice daily and at least as effective as the prostaglandin analogues 0.005% latanoprost and 0.004% travoprost once daily in terms of reducing IOP and/or achieving target IOP levels. Bimatoprost was also more effective than twice-daily administration of 0.5%/2% timolol/dorzolamide in patients refractory to topical timolol therapy. Although generally well tolerated, bimatoprost is associated with a higher incidence of conjunctival hyperaemia than latanoprost, timolol or the combination of timolol and dorzolamide. Three fully published modelled cost-effectiveness analyses of bimatoprost evaluating cost per treatment success in patients with glaucoma or ocular hypertension have been conducted in the US. The analyses incorporated results of randomised, multicentre clinical trials and used a 1-year time horizon. In the treatment algorithm used in the models, patients not achieving target IOP levels with bi...Continue Reading

References

Oct 29, 1998·The New England Journal of Medicine·W L Alward
Jul 17, 1999·International Journal of Technology Assessment in Health Care·G Kobelt, L Jönsson
Jul 22, 1999·The British Journal of Ophthalmology·J R Stephenson
Sep 27, 2001·Advances in Therapy·S GandolfiUNKNOWN Bimatoprost Study Group 3
May 25, 2002·Drugs & Aging·Stephanie E Easthope, Caroline M Perry
Nov 5, 2002·Ophthalmology·Tony Realini, Robert D Fechtner

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Citations

May 20, 2006·Current Medical Research and Opinion·David Covert, Alan L Robin
Feb 18, 2009·Drugs & Aging·Monique P Curran, Jennifer S Orman
Oct 31, 2009·Expert Opinion on Pharmacotherapy·A Jayaprakash PatilDeepak P Edward
Oct 17, 2006·Wiener medizinische Wochenschrift·Hemma Resch, Gerhard Garhofer
Jan 1, 2008·Journal of Medical Economics·Daniela KolevaLivio Garattini

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