Bimatoprost versus Mometasone Furoate in the Treatment of Scalp Alopecia Areata: A Pilot Study

Dermatology : International Journal for Clinical and Investigative Dermatology
Hesham ZaherMarwa Hassan

Abstract

Alopecia areata (AA) is an immune-mediated disease that targets anagen hair follicles. Despite various therapeutic options, there is no cure for AA. Prostaglandin analogues have been recognized as being capable of inducing hypertrichosis. To compare the efficacy and safety of bimatoprost to those of corticosteroid in the treatment of scalp AA. Thirty adult patients with patchy AA (S1) were included. Two AA patches were randomly assigned to treatment either by mometasone furoate 0.1% cream once daily (area A) or bimatoprost 0.03% solution twice daily (area B) for 3 months. Patients were assessed using the Severity of Alopecia Tool (SALT) scoring system for hair re-growth. All responding AA patches showed significant reduction in their SALT score after therapy. Area B demonstrated significantly better results regarding rapidity of response in weeks, percentage of hair re-growth and side effects compared to area A. Bimatoprost solution represents a therapeutic option for scalp AA.

Citations

Jul 6, 2016·Pediatric Dermatology·Alvin W Li, Richard J Antaya
Oct 23, 2016·American Journal of Clinical Dermatology·Aditya K GuptaWilliam Abramovits
Mar 8, 2017·Expert Opinion on Investigational Drugs·Yevher Lorena Barrón-Hernández, Antonella Tosti
May 20, 2017·The Journal of Dermatological Treatment·Amal Ahmad El-AshmawyGamal Mohamed El-Maghraby
Jun 22, 2017·The Journal of Dermatology·Solam Lee, Won-Soo Lee
Dec 15, 2020·Dermatologic Therapy·Nafise YazdanianAzadeh Goodarzi
Dec 19, 2020·Clinical, Cosmetic and Investigational Dermatology·Sudhir M BaswanNathan Stern
Aug 18, 2021·Clinical Reviews in Allergy & Immunology·Cheng ZhouJianzhong Zhang

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