Bimetallic Oxide MnMoOX Nanorods for in Vivo Photoacoustic Imaging of GSH and Tumor-Specific Photothermal Therapy

Nano Letters
Fei GongZhuang Liu

Abstract

Accurate imaging of glutathione (GSH) in vivo is able to provide real-time visualization of physiological and pathological conditions. Herein, we successfully synthesize bimetallic oxide MnMoOX nanorods as an intelligent nanoprobe for in vivo GSH detection via photoacoustic (PA) imaging. The obtained MnMoOX nanoprobe with no near-infrared (NIR) absorption in the absence of GSH would exhibit strong GSH-responsive NIR absorbance, endowing PA imaging detection of GSH. Due to the up-regulated GSH concentration in the tumor microenvironment, our MnMoOX nanoprobe could be utilized for in vivo tumor-specific PA imaging. Moreover, MnMoOX nanorods with GSH-responsive NIR absorbance could also be employed to achieve tumor-specific photothermal therapy (PTT). Importantly, such MnMoOX nanorods show inherent biodegradability and could be rapidly cleared out from the body, minimizing their long-term body retention and potential toxicity. Our work presents a new type of GSH-responsive nanoprobe based on bimetallic oxide nanostructures, promising for tumor-specific imaging and therapy.

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Citations

Dec 1, 2018·Nanoscale·Jing-Jing HuXian-Zheng Zhang
Mar 23, 2019·Biomaterials Science·Mirko MaturiMauro Comes Franchini
May 9, 2019·Journal of Biomedical Materials Research. Part a·Sheng WangJie Tan
Jan 14, 2020·Advanced Materials·Huijing XiangYu Chen
Feb 27, 2020·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Chen DaiBo Zhang
Jul 12, 2019·Advanced Drug Delivery Reviews·Colman MooreJesse V Jokerst
Oct 21, 2020·Advanced Drug Delivery Reviews·Ke LiXian-Zheng Zhang
Mar 17, 2021·Advanced Biology·Tiancong Ma, Tian Xia
Mar 27, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Namdev DhasTejal Mehta
Nov 14, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Junlie YaoAiguo Wu
Apr 22, 2021·Biomedical Materials·Mengjiao ZhouHaijun Yu
Jun 23, 2021·Chemical Society Reviews·Xianwen WangLiang Cheng
Jul 12, 2021·Journal of Nanobiotechnology·Tong ChenXiang Li
Sep 9, 2019·ACS Biomaterials Science & Engineering·Xuwu ZhangDawei Gao
Dec 29, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Changchun WenHong Liang
Jul 16, 2019·The Journal of Physical Chemistry. B·Mengya LiHonglai Liu
Feb 19, 2020·Analytical Chemistry·Mei-Rong CuiHong-Yuan Chen

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