Bimoclomol protects against vascular consequences of experimental subarachnoid hemorrhage in rats

Brain Research Bulletin
F Erdö, S L Erdö

Abstract

Bimoclomol (BRLP-42) is a novel antiischemic compound acting against peripheral vascular complications of diabetes mellitus (neuropathy, retinopathy, and nephropathy). In the present study the activity of bimoclomol was tested in experimental subarachnoid hemorrhage (SAH) and arachidonic acid (AA)-induced brain edema in rats to elucidate whether the compound may also have beneficial effect in cerebrovascular disturbances. For comparison, a neuroprotective AMPA antagonist, GYKI-52466, was examined. Injury caused by autologous intracranial blood injection or sodium-arachidonate was evaluated by the damage of blood-brain barrier (BBB) reflected in the extravasation of Evans blue dye into the cerebral tissue. Bimoclomol (2 x 2 mg/kg IV) markedly reduced, while GYKI-52466 (2 x 2 mg/kg IV) moderately diminished the extravasation produced by SAH (39.9%, p < 0.01 and 26.7%, p > 0.05, respectively). In the case of AA-induced brain edema, bimoclomol showed less pronounced (19.6%, p < 0.05) inhibitory action, and GYKI-52466 seemed to be more effective (34.2%, p < 0.05). These results suggest that bimoclomol may be active not only in peripheral micro- and macroangiopathy, but also in some types of cerebrovascular disorders.

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Citations

Jan 16, 2002·European Journal of Pharmacology·James S PolakowskiBryan F Cox
Feb 11, 2014·Translational Stroke Research·Michael K Tso, R Loch Macdonald
Mar 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Zsolt TörökLászló Vigh
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Aug 8, 2006·Toxicology Letters·Alessandra StacchiottiLuigi Fabrizio Rodella
Jan 25, 2018·International Journal of Molecular Sciences·Botond PenkeLászló Vígh
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Nov 4, 2005·Journal of the American Animal Hospital Association·P Filippo AdamoRebecca L Stepien
Jan 7, 2005·Cell Stress & Chaperones·Dai YanKenzo Ohtsuka

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