Abstract
Bimoclomol (BRLP-42) is a novel antiischemic compound acting against peripheral vascular complications of diabetes mellitus (neuropathy, retinopathy, and nephropathy). In the present study the activity of bimoclomol was tested in experimental subarachnoid hemorrhage (SAH) and arachidonic acid (AA)-induced brain edema in rats to elucidate whether the compound may also have beneficial effect in cerebrovascular disturbances. For comparison, a neuroprotective AMPA antagonist, GYKI-52466, was examined. Injury caused by autologous intracranial blood injection or sodium-arachidonate was evaluated by the damage of blood-brain barrier (BBB) reflected in the extravasation of Evans blue dye into the cerebral tissue. Bimoclomol (2 x 2 mg/kg IV) markedly reduced, while GYKI-52466 (2 x 2 mg/kg IV) moderately diminished the extravasation produced by SAH (39.9%, p < 0.01 and 26.7%, p > 0.05, respectively). In the case of AA-induced brain edema, bimoclomol showed less pronounced (19.6%, p < 0.05) inhibitory action, and GYKI-52466 seemed to be more effective (34.2%, p < 0.05). These results suggest that bimoclomol may be active not only in peripheral micro- and macroangiopathy, but also in some types of cerebrovascular disorders.
References
Apr 27, 1992·Neuroscience Letters·S ShimosakaR P Simon
Feb 11, 1990·Journal of Neurochemistry·T S NowakM J Schlesinger
May 11, 1990·Journal of Neurochemistry·A M MariniT S Nowak
Dec 1, 1991·Neuron·G RordorfJ V Bonventre
Dec 1, 1991·Neuron·D H LowensteinM F Miles
Jul 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F R SharpK Hisanaga
Oct 29, 1990·Brain Research·D H LowensteinF R Sharp
Mar 1, 1989·Stroke; a Journal of Cerebral Circulation·M Zuccarello, D K Anderson
Aug 22, 1989·European Journal of Pharmacology·I TarnawaF Andrási
May 22, 1989·Neuroscience Letters·K VassH Lassmann
Nov 1, 1985·Journal of Neurochemistry·T S Nowak
Jun 1, 1983·Annals of Neurology·P H ChanJ Lee
Feb 18, 1994·Brain Research. Developmental Brain Research·O OsipenkoE S Vizi
Jan 1, 1995·Brain Research Bulletin·K SangoT Takenaka
Jan 1, 1995·Brain Research Bulletin·P Marfaing-JallatL Pénicaud
Dec 27, 1994·European Journal of Pharmacology·G LombardiF Moroni
Dec 1, 1994·British Journal of Pharmacology·W Löscher, D Hönack
Dec 1, 1994·Diabetologia·N E CameronM A Cotter
Sep 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H KinouchiT Yoshimoto
Dec 12, 1993·Neuroscience Letters·R P SimonR Gwinn
Mar 1, 1996·Stroke; a Journal of Cerebral Circulation·P MatzF R Sharp
Oct 1, 1996·Stroke; a Journal of Cerebral Circulation·M ZuccarelloR M Rapoport
Jan 1, 1997·Brain Research Bulletin·K BíróL Korányi
Citations
Feb 5, 2013·Molecular Neurobiology·Deepak Chhangani, Amit Mishra
Jan 16, 2002·European Journal of Pharmacology·James S PolakowskiBryan F Cox
Mar 31, 1999·Neurochemistry International·E TóthA Lajtha
Oct 10, 2002·Brain Research Bulletin·Ildikó VilágiIstván Tarnawa
Jul 23, 1998·Neuroreport·K BíróG Juhász
Feb 11, 2014·Translational Stroke Research·Michael K Tso, R Loch Macdonald
Mar 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Zsolt TörökLászló Vigh
Dec 13, 2012·Neuroscience·P K NayakD S Kerr
Aug 2, 2003·Biochemical and Biophysical Research Communications·Judit HargitaiDavid S Latchman
May 15, 2015·Progress in Lipid Research·Pablo V EscribáLászló Vígh
Jul 5, 2005·Expert Opinion on Therapeutic Targets·M Tytell, P L Hooper
Jan 1, 2014·Biochimica Et Biophysica Acta·Zsolt TörökLászló Vigh
Aug 8, 2006·Toxicology Letters·Alessandra StacchiottiLuigi Fabrizio Rodella
Jan 25, 2018·International Journal of Molecular Sciences·Botond PenkeLászló Vígh
Dec 8, 1998·Reviews on Environmental Health·E MariéthozB S Polla
Jan 16, 2020·Cell Stress & Chaperones·Qingkang LyuFemke Broere
Aug 3, 2001·Cardiovascular Drug Reviews·P P Nánási, A Jednákovits
Dec 13, 2005·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·K OhtsukaK Saito
Nov 4, 2005·Journal of the American Animal Hospital Association·P Filippo AdamoRebecca L Stepien
Jan 7, 2005·Cell Stress & Chaperones·Dai YanKenzo Ohtsuka
Aug 4, 2021·Translational Stroke Research·Fumihiro KawakitaHidenori Suzuki