Bimodal distribution of vasodilator responsiveness to adenosine due to difference in nitric oxide contribution: implications for exercise hyperemia

Journal of Applied Physiology
Elizabeth A MartinMichael J Joyner

Abstract

To gain insight into the role of adenosine (Ado) in exercise hyperemia, we compared forearm vasodilation induced by intra-arterial infusion of three doses of Ado with vasodilation during three workloads of forearm handgrip exercise in 27 human subjects. We measured forearm blood flow (FBF) using Doppler ultrasound and mean arterial pressure (MAP) via brachial artery catheters and calculated forearm vascular conductance (FVC = FBF/MAP) during each infusion dose or workload. We found that about half of the subjects demonstrated robust vasodilator responsiveness to both Ado infusion and exercise, and the other half demonstrated blunted vasodilator responsiveness to Ado infusion compared with exercise. In 15 subjects (identified as "Ado responders"), the change in FVC above baseline was 209 +/- 33, 419 +/- 57, and 603 +/- 75 ml.min(-1).100 mmHg(-1) for the low, medium, and high doses of Ado, respectively, and 221 +/- 35, 413 +/- 54, and 582 +/- 70 ml.min(-1).100 mmHg(-1) for the low, medium, and high exercise workloads, respectively. In the other 12 subjects (identified as "Ado nonresponders"), the change in FVC above baseline was 102 +/- 36, 113 +/- 42, and 151 +/- 54 ml.min(-1).100 mmHg(-1) for the low, medium, and high doses of ...Continue Reading

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Citations

Sep 29, 2011·European Journal of Applied Physiology·Marcos G LopezDarren P Casey
Jun 14, 2012·European Journal of Applied Physiology·Darren P CaseyMichael J Joyner
Sep 5, 2009·Journal of Applied Physiology·Darren P Casey, Michael J Joyner
Sep 20, 2008·Journal of Applied Physiology·Manabu ShibasakiCraig G Crandall
Dec 18, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Terry E GrahamFarah S L Thong
Feb 2, 2011·The Journal of Physiology·Darren P CaseyMichael J Joyner
Apr 18, 2008·European Journal of Pharmacology·Niels P RiksenPaul Smits
Dec 2, 2009·The Journal of Physiology·Darren P CaseyMichael J Joyner
Jul 7, 2007·The Journal of Physiology·Janice M Marshall
Dec 26, 2016·European Journal of Applied Physiology·Jacqueline K LimbergTimothy B Curry
Feb 14, 2017·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Guus A de WaardNiels van Royen
Oct 21, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Daniel J GreenKeith George
Feb 26, 2019·Physiological Reports·Sushant M RanadiveMichael J Joyner
Dec 2, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ilkka HeinonenKari K Kalliokoski
Nov 26, 2019·Experimental Physiology·Gabrielle A DillonSushant M Ranadive
Mar 13, 2012·American Journal of Physiology. Heart and Circulatory Physiology·S P MortensenB Saltin
May 30, 2015·Journal of Applied Physiology·Darren P CaseyMichael J Joyner
Dec 22, 2020·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Takumi ToyaAmir Lerman

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