Bimodal effect of retinoic acid on melanocyte differentiation identified by time-dependent analysis

Pigment Cell & Melanoma Research
Yu InoueHirohiko Akamatsu

Abstract

Retinoic acid (RA) is considered to control melanocytes; however, its precise mechanism remains unclear because of a bimodal effect, which promotes or inhibits melanin synthesis depending on the cell type, culture condition of melanocytes and skin conditions. In this study, we examined the effects of RA throughout each stage of differentiation of melanocytes using a mouse embryonic stem cell culture system to induce melanocytes. The results showed that RA has significantly different effects depending on the stage of differentiation of melanocytes. More specifically, RA promoted differentiation in earlier stages, wherein embryonic stem cells became melanoblasts via neural crest cells, and inhibited differentiation in later stages, wherein melanoblasts became melanocytes. It was revealed for the first time that melanocytes show markedly different reactions to RA depending on the stage of differentiation.

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Citations

Nov 6, 2013·Biological & Pharmaceutical Bulletin·Yu InoueHirohiko Akamatsu
Aug 19, 2014·Journal of Dermatological Science·Hyunjung ChoiMinsoo Noh
Aug 16, 2014·Bioorganic & Medicinal Chemistry·Noriko TakahashiYu Komori
Jan 5, 2017·The Journal of Dermatology·Tamihiro KawakamiYoshinao Soma
Oct 14, 2017·International Journal of Toxicology·Wilbur Johnson
Feb 11, 2020·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Qiran ChenTohru Suzuki
Jul 28, 2020·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Emmanuelle Tancrède-BohinAna-Maria Pena

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