Bimodal Respiratory-Locomotor Neurons in the Neonatal Rat Spinal Cord

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Jean-Patrick Le GalDidier Morin

Abstract

Neural networks that can generate rhythmic motor output in the absence of sensory feedback, commonly called central pattern generators (CPGs), are involved in many vital functions such as locomotion or respiration. In certain circumstances, these neural networks must interact to produce coordinated motor behavior adapted to environmental constraints and to satisfy the basic needs of an organism. In this context, we recently reported the existence of an ascending excitatory influence from lumbar locomotor CPG circuitry to the medullary respiratory networks that is able to depolarize neurons of the parafacial respiratory group during fictive locomotion and to subsequently induce an increased respiratory rhythmicity (Le Gal et al., 2014b). Here, using an isolated in vitro brainstem-spinal cord preparation from neonatal rat in which the respiratory and the locomotor networks remain intact, we show that during fictive locomotion induced either pharmacologically or by sacrocaudal afferent stimulation, the activity of both thoracolumbar expiratory motoneurons and interneurons is rhythmically modulated with the locomotor activity. Completely absent in spinal inspiratory cells, this rhythmic pattern is highly correlated with the hindlim...Continue Reading

Citations

Feb 27, 2018·Frontiers in Neuroscience·Céline Jean-Xavier, Marie-Claude Perreault
Mar 10, 2020·The European Journal of Neuroscience·Jean-Patrick Le GalDidier Morin
Apr 12, 2019·Frontiers in Neuroscience·Natalia A ShevtsovaTatiana Bezdudnaya
Aug 30, 2017·Frontiers in Neural Circuits·Zhao-Zhe Hao, Ari Berkowitz
Oct 17, 2019·The Journal of Experimental Biology·Ari Berkowitz
Feb 6, 2020·Frontiers in Systems Neuroscience·Victoria N JensenSteven A Crone
Jul 19, 2018·Trends in Neurosciences·Lyandysha V ZholudevaMichael A Lane
Aug 28, 2021·International Journal of Molecular Sciences·Maxime LemieuxFrédéric Bretzner

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