Bimodal transcranial direct current stimulation reduces alcohol consumption and induces long-term neurochemical changes in rats with neuropathic pain.

Neuroscience Letters
Daniela Silva SantosIraci L S Torres

Abstract

This study aimed to evaluate the effects of repeated bimodal transcranial direct current stimulation (tDCS) on alcohol consumption and immunohistological and neurochemical parameters in nerve-injured rats. Forty-eight adult male Wistar rats were distributed into six groups: control, neuropathic pain (NP) + sham-tDCS, NP + alcohol + sham-tDCS, alcohol + sham-tDCS, alcohol + tDCS, and NP + alcohol + tDCS. NP is induced by chronic sciatic nerve constriction (CCI). The rats were exposed to a 10% alcohol solution by voluntary consumption for 14 days. From the 16th day after surgery, bimodal tDCS was applied for 20 min/day for 8 days. Brain structures were collected to evaluate the number of neuropeptide Y (NPY)-positive neurons, neurites, and argyrophilic grains by immunohistochemistry, and brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), interleukin (IL)-6, and IL-10 by ELISA. Nerve-injured rats showed a progressive increase in alcohol consumption compared to the non-injured rats. In addition, there was a reduction in voluntary alcohol consumption over time induced by tDCS. Alcohol exposure, chronic pain, and tDCS treatment modulated the central NPY immunoreactivity. tDCS increased the cerebellar levels of IL-6 ...Continue Reading

References

Nov 16, 1995·Nature·M D'EspositoM Grossman
Aug 10, 2000·Experimental Brain Research·J M Fuster
May 17, 2005·European Journal of Pharmacology·Marianna Eunsun JungJames William Simpkins
Apr 1, 2006·Alcoholism, Clinical and Experimental Research·Fulton T CrewsJian Zou
Jun 17, 2006·Annual Review of Neuroscience·Steven E HymanEric J Nestler
Aug 29, 2009·The Journal of Pain : Official Journal of the American Pain Society·Joseph L Riley, Christopher King
Feb 13, 2010·Addiction Biology·Markus HeiligHoward C Becker
Mar 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Nora D VolkowFrank Telang
May 26, 2012·PloS One·Heidi M B LesscherLouk J M J Vanderschuren
Sep 15, 2012·Neuroscience and Biobehavioral Reviews·Mark EgliScott Edwards
Oct 16, 2012·Brain Research·Lauren Naomi Spezia AdachiIraci L S Torres
Apr 3, 2013·Nature Reviews. Rheumatology·Luda DiatchenkoWilliam Maixner
May 22, 2013·Neuropharmacology·Pedro BekinschteinJorge H Medina
Aug 27, 2014·Alcoholism, Clinical and Experimental Research·Tamara L Doremus-FitzwaterTerrence Deak
May 12, 2015·Journal of Pain Research·Claudia Horn-HofmannJörg Wolstein
May 28, 2015·Pharmacology, Biochemistry, and Behavior·Rebeca Vargas Antunes SchunckMirna Bainy Leal
Jul 15, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Paulo Ricardo Marques FilhoIraci L S Torres
Nov 21, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean-Pascal LefaucheurWalter Paulus
Nov 24, 2016·Seizure : the Journal of the British Epilepsy Association·Andreas Schulze-Bonhage
Dec 7, 2016·The Journal of Pain : Official Journal of the American Pain Society·Trevor ThompsonBrendon Stubbs
Aug 22, 2017·Frontiers in Endocrinology·Annika Thorsell, Aleksander A Mathé
Sep 12, 2017·Neuroscience·Marta Diaz-delCastilloAnne Marie Heegaard
Mar 17, 2018·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·J Ryan ScottSteven E Harte

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