Binary and ternary new water soluble copper(II) complexes of l-tyrosine and substituted 1,10-phenanthrolines: effect of substitution on DNA interactions and cytotoxicities

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Duygu İnciTolga Cavaş

Abstract

Binary and ternary water soluble copper(II) complexes - [Cu(nphen)2(H2O)](NO3)2·H2O (1), [Cu(phen)2(H2O)](NO3)2 (2), [Cu(nphen)(l-tyr)(H2O)]NO3·2H2O (3), [Cu(phen)(tyr)(H2O)] NO3·2H2O (4) - and diquarternary salts of nphen and phen (nphen=5-nitro-1,10-phenanthroline, phen=1,10-phenanthroline and tyr=l-tyrosine) have been synthesized and characterized by CHN analysis, (1)H NMR, (13)C NMR and IR spectroscopy, thermal analysis and single crystal X-ray diffraction techniques. The CT-DNA binding properties of these compounds have been investigated by thermal denaturation measurements, absorption and emission spectroscopy. The supercoiled pUC19 plasmid DNA cleavage activity of these compounds has been explored by agarose gel electrophoresis. The cytotoxicity of these compounds against MCF-7, Caco-2, A549 cancer cells and BEAS-2B healthy cells was also studied by using XTT method. The complexes 1-4 exhibit significant high cytotoxicity with low IC50 values in compared with cisplatin. The effect of the substituents of phen and coordinated amino acid in the above complexes are presented and discussed.

References

Oct 7, 1993·Nature·Y KimP B Sigler
Oct 27, 2004·Biochemistry·Tim PhillipsJim A Thomas
Feb 10, 2009·Anti-cancer Agents in Medicinal Chemistry·Cristina MarzanoCarlo Santini
Apr 10, 2009·Current Medicinal Chemistry·Saverio Tardito, Luciano Marchiò
Feb 24, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Zhousheng YangGeng Yang
May 24, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J Serment-GuerreroL Ruiz-Azuara
Dec 22, 2011·Metallomics : Integrated Biometal Science·Clare Duncan, Anthony R White

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Citations

Nov 11, 2016·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Duygu İnciNilüfer Çinkılıç
Jan 18, 2016·Journal of Inorganic Biochemistry·Wei Chuan ZhangXiaoming Lu
Mar 11, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Meidie HuYunsheng Liao

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