Binding characteristics of 3H-prazosin to rat brain alpha-adrenergic receptors

European Journal of Pharmacology
P Greengrass, R Bremner

Abstract

3H-Prazosin binding to membranes from rat brain is saturable, Bmax, 77 fmol/mg protein, of high affinity, KD, 0.28 nM and with a drug specificity indicating that it labels alpha-adrenergic receptors. The ranking of alpha-antagonists for these binding sites suggests that 3H-prazosin may be useful in identifying a subpopulation of alpha-receptors (alpha1) in the central nervous system.

References

May 22, 1994·The Journal of Comparative Neurology·G FlüggeE Fuchs
Jun 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·G Gross, I Lues
May 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·P J MiachP Meyer
Nov 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·H W WetzelS Z Langer
Nov 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·D B MenkesG K Aghajanian
Feb 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·M J MorrisP Meyer
Jan 1, 1983·Journal of Neural Transmission·K G CharltonD E Clarke
Jan 1, 1993·Psychopharmacology·C F Saller, A I Salama
Nov 1, 1988·Biological Psychiatry·O T Osman, R E Becker
Nov 26, 1984·Brain Research·R CashY Agid
Oct 3, 1980·European Journal of Pharmacology·J S KarlinerC Dollery
Feb 1, 1980·European Journal of Pharmacology·P B Timmermans, P A Van Zwieten
Jul 17, 1981·European Journal of Pharmacology·G Engel, D Hoyer
Feb 19, 1982·European Journal of Pharmacology·M R Dashwood, J Bagnall
Dec 17, 1982·European Journal of Pharmacology·A Noguchi, J A Whitsett
Dec 17, 1982·European Journal of Pharmacology·M R Dashwood
Jan 28, 1983·European Journal of Pharmacology·D B MenkesD W Gallager
Aug 5, 1983·European Journal of Pharmacology·G A McPherson, P M Beart
Nov 27, 1984·European Journal of Pharmacology·A G Ramage
Sep 3, 1984·European Journal of Pharmacology·F HataH Ishida
Jan 2, 1985·European Journal of Pharmacology·F HataH Ishida
Feb 5, 1985·European Journal of Pharmacology·R CashY Agid

Citations

Jul 1, 1978·European Journal of Pharmacology·D C U'PrichardS H Snyder
Mar 31, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·K StarkeE Borowski

Related Concepts

Tissue Membrane
Brain
Adrenergic alpha-Agonists
Adrenergic alpha-Antagonists
Plasma Protein Binding Capacity
Quinazolines
Norepinephrine Receptors
Pratsiol
Alpha-adrenergic receptor
In Vitro [Publication Type]

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