Binding characteristics of 3H-prazosin to rat brain alpha-adrenergic receptors

European Journal of Pharmacology
P Greengrass, R Bremner


3H-Prazosin binding to membranes from rat brain is saturable, Bmax, 77 fmol/mg protein, of high affinity, KD, 0.28 nM and with a drug specificity indicating that it labels alpha-adrenergic receptors. The ranking of alpha-antagonists for these binding sites suggests that 3H-prazosin may be useful in identifying a subpopulation of alpha-receptors (alpha1) in the central nervous system.


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Related Concepts

Tissue Membrane
Adrenergic alpha-Agonists
Adrenergic alpha-Antagonists
Plasma Protein Binding Capacity
Norepinephrine Receptors
Alpha-adrenergic receptor
In Vitro [Publication Type]

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