PMID: 64005Oct 1, 1976Paper

Binding of [3H] methyltrienolone (R 1881) in rat prostate and human benign prostatic hypertrophy (BPH)

Steroids
J AsselinJ P Raynaud

Abstract

Methyltrienolone (R 1881 - 17beta-hydroxy-17alpha-methyl-estra-4, 9, 11-trien-3-one) binding to rat ventral prostate cytosol has a specificity typical of an androgen receptor. In human benign prostatic hypertrophy (BPH) tissue, the specificity of [3H] R 1881 binding is different from that measured in rat prostate: progesterone and R 5020 (17, 21-dimethyl-19-nor-4, 9-pregnadiene-3, 20-dione) being more potent while 19-nortestosterone is less potent competitor. Moreover, the synthetic progestin [3H] R 5020 binds to BPH tissue with a similar specificity. These data suggest the presence of progestin binding components or of an atypical androgen receptor in human BPH cytosol.

References

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Citations

Jan 1, 1978·Journal of Supramolecular Structure·F S MarklandE B Howard
Apr 13, 1981·Molecular and Cellular Biochemistry·T R Brown, C J Migeon
Feb 1, 1979·Journal of Steroid Biochemistry·G Verhoeven
Jul 1, 1979·Journal of Steroid Biochemistry·K F StøaP A Høisaeter
Apr 1, 1979·Journal of Steroid Biochemistry·J Y DubéP Chapdelaine
Apr 1, 1979·Journal of Steroid Biochemistry·J Y DubéR R Tremblay
Nov 1, 1980·Journal of Steroid Biochemistry·R S CalandraR C Terrab
May 1, 1980·Journal of Steroid Biochemistry·G Verhoeven
Jan 1, 1980·Journal of Steroid Biochemistry·J P RaynaudJ P Mornon
Dec 1, 1981·Journal of Steroid Biochemistry·M M BoutonJ A Grandadam
Jun 1, 1983·Journal of Steroid Biochemistry·N BashirelahiJ D Young
Mar 1, 1984·Journal of Steroid Biochemistry·S L SchneiderA A Sandberg
Aug 1, 1988·Journal of Steroid Biochemistry·W S StebbingsG P Vinson
Jan 1, 1988·Pharmacology & Therapeutics·A A Sandberg, R Y Kirdani
Sep 1, 1978·Molecular and Cellular Endocrinology·E MulderR Oftebro
Mar 1, 1985·Molecular and Cellular Endocrinology·S M CampoJ K Findlay
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Jul 1, 1981·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A L LinS A Shain

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