Binding of [3H]cimetidine to rat brain tissue

Agents and Actions
I R SmithK M Metters

Abstract

Binding of [3H]cimetidine to rat brain tissue was investigated, and a saturable binding with dissociation constant 0.22 +/- 0.05 microM found. This binding is inhibited by a range of imidazole-derived histamine H2-receptor antagonists, but not by a number of non-imidazole H2-receptor antagonists. It is concluded that the [3H]cimetidine binding site in rat brain tissue that is labelled in these experiments is not the histamine H2-receptor.

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Citations

Oct 1, 1993·Journal of Clinical Pharmacology·C W Berthold, R A Dionne
Aug 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·A SchotteP M Laduron
Nov 1, 1986·Agents and Actions·I R SmithM E Mylek
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Oct 28, 2020·Journal of Medicinal Chemistry·Katharina TropmannSteffen Pockes

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