PMID: 3894801Jun 1, 1985Paper

Binding of activated progesterone receptor to microsomes

Journal of Steroid Biochemistry
A J WolfsonD H Seeley


Specific binding of steroid hormones to microsomes has been reported for several tissues. In the hen oviduct, this receptor appears to be very similar to activated cytosolic receptor. The microsomal receptor is readily solubilized, and resembles the cytosolic receptor in all physico-chemical characteristics: sedimentation coefficient approximately 4 S, Stokes radius 5.5 nm, slow dissociation rate of the complex, adsorption to polyanions. It is precipitated by an antibody to the cytosolic receptor. Microsomes display saturable binding of cytosolic receptor, with a Bmax of approximately 300 fmol/mg protein. This binding is also observed using microsomes from non-target tissues, and is decreased by treatment with RNase. It seems likely that microsomal binding is due to the high affinity of activated cytosolic receptor for RNA.


Sep 1, 1975·Journal of Steroid Biochemistry·M Haukkamaa, T Luukkainen
Apr 1, 1990·Pathology·G A TallisR Bais
Dec 4, 1973·Biochemistry·E MilgromE E Baulieu
May 20, 1974·Biochimica Et Biophysica Acta·B M AndersonT L Fisher
Nov 27, 1974·Biochimica Et Biophysica Acta·P RobelE E Baulieu
Jul 1, 1971·The Biochemical Journal·C M SzegoJ A Roberts
Aug 1, 1982·Biochemical and Biophysical Research Communications·A O Niemelä, P J Tuohimaa
Aug 1, 1980·Molecular and Cellular Endocrinology·M HaukkamaaP Tuohimaa
Jan 8, 1980·Biochemistry·H Nishigori, D Toft
Jun 1, 1980·Journal of Steroid Biochemistry·R Drangova, G Feuer
Aug 29, 1980·Biochemical and Biophysical Research Communications·A WolfsonY Chang-Ren

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.