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Binding of an imidazolidine (clonidine), an oxazoloazepin (B-HT 933) and a thiazoloazepin (B-HT 920) to rat brain alpha-adrenoceptors and relation to cardiovascular effects

European Journal of Pharmacology

Apr 4, 1980

R HammerL Pichler

Abstract

The specific binding to alpha-adrenoceptors in crude plasma membrane preparations of the rat brain was studied by means of 3H-clonidine (specific radioactivity 26.7 Ci/mmole). Equilibrium binding of 3H-clonidine could be described adequately according to a two-site model with a minor po...read more

Mentioned in this Paper

Blood Vessel
Diastolic Blood Pressure
Brain
Azepines
Cardiovascular Diseases
Adrenergic Receptor
Norepinephrine Receptors
Blood Pressure
Rat Brain
Thiazoles
Paper Details
References
  • References7
  • Citations36
1234

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Binding of an imidazolidine (clonidine), an oxazoloazepin (B-HT 933) and a thiazoloazepin (B-HT 920) to rat brain alpha-adrenoceptors and relation to cardiovascular effects

European Journal of Pharmacology

Apr 4, 1980

R HammerL Pichler

PMID: 6245898

DOI: 10.1016/0014-2999(80)90095-3

Abstract

The specific binding to alpha-adrenoceptors in crude plasma membrane preparations of the rat brain was studied by means of 3H-clonidine (specific radioactivity 26.7 Ci/mmole). Equilibrium binding of 3H-clonidine could be described adequately according to a two-site model with a minor po...read more

Mentioned in this Paper

Blood Vessel
Diastolic Blood Pressure
Brain
Azepines
Cardiovascular Diseases
Adrenergic Receptor
Norepinephrine Receptors
Blood Pressure
Rat Brain
Thiazoles

Similar Papers Found In These Feeds

GPCRs in Blood Pressure Regulation

Blood pressure is tightly regulated by blood vessel radius, which is established by hormones and/or peptides binding to GPCRs (G-protein-coupled receptors). Discover the latest research on GPCRs in blood pressure regulation here

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Related Papers

Paper Details
References
  • References7
  • Citations36
1234
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