PMID: 486Nov 1, 1975

Binding of bile acids to cholestyramine at gastric pH conditions

Journal of Pharmaceutical Sciences
S Lindenbaum, T Higuchi


The binding of bile salts to cholestyramine was studied under varying conditions of pH and added electrolyte. The taurine-conjugated bile salts were strongly absorbed by the anion-exchange resin at low pH and in the presence of chloride anions. Glycocholic acid binding was very weak at low pH but increased strongly with increasing pH. The presence of chloride ions strongly decreased the amount of glycocholate bound by the anion-exchange resin.


May 30, 2001·Journal of Pharmaceutical and Biomedical Analysis·M A SchreiberP K Hovsepian
Mar 1, 1995·The Journal of Pharmacy and Pharmacology·H N Joshi, T D Wilson
Jan 1, 1995·Journal of Pharmaceutical Sciences·J E Polli, G L Amidon
Jan 1, 1992·Journal of Pharmaceutical Sciences·X X ZhuL E St-Pierre

Related Concepts

Bile Salts
Deoxycholic Acid, Sodium Salt, 12beta-Isomer
Glycocholate Sodium
Hydrogen-Ion Concentration
Taurocholic Acid, Monolithium Salt

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