Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors.

Cell Death & Disease
Y ZhangB Yan

Abstract

Biomaterials that can drive stem cells to an appropriate differentiation level and decrease apoptosis of transplanted cells are needed in regenerative medicine. Nanomaterials are promising novel materials for such applications. Here we reported that carboxylated multiwalled carbon nanotube (MWCNT 1) promotes myogenic differentiation of mouse myoblast cells and inhibits cell apoptosis under the differentiation conditions by regulating basic helix-loop-helix transcription factors. MWCNT 1 attenuates bone morphogenetic protein receptor (BMPR) signaling activity by binding to BMPR2 and attenuating the phosphorylation of BMPR1. This molecular understanding allowed us to tune stem cell differentiation to various levels by chemical modifications, demonstrating human control of biological activities of nanoparticles and opening an avenue for potential applications of nanomaterials in regenerative medicine.

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Citations

Aug 28, 2012·International Journal of Nanomedicine·Fernanda M P TonelliRodrigo R Resende
Jul 17, 2013·Advanced Drug Delivery Reviews·Alessandra FabbroLaura Ballerini
Feb 2, 2016·Toxicology and Applied Pharmacology·Liming Wang, Chunying Chen
Nov 28, 2012·Advanced Healthcare Materials·Sook Hee KuChan Beum Park
Dec 24, 2014·Chemical Research in Toxicology·Yi ZhangBing Yan
Nov 7, 2016·Particle and Fibre Toxicology·Jie Dong, Qiang Ma
Jun 20, 2017·Biotechnology and Bioengineering·Yuta KurashinaKenjiro Takemura
Mar 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hainan SunBing Yan

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Methods Mentioned

BETA
transgenic
immunoprecipitation
nuclear translocation
co-immunoprecipitation assay
co-immunoprecipitation
proximity ligation assay
fluorescence resonance
FRET
chemical modifications
ChIP

Software Mentioned

SigmaPlot
cellSen Dimension
Zen

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