PMID: 8948479Nov 13, 1996Paper

Binding of daidzein to liposomes

Biochimica Et Biophysica Acta
J Y LehtonenP K Kinnunen

Abstract

Turbidity and differential scanning calorimetry measurements revealed the plant derived antineoplastic isoflavone, daidzein, to bind to large unilamellar liposomes. Comparing different unsaturated phospholipids most pronounced aggregation due to daidzein was observed for phosphatidylinositol (PI) while the inclusion of cholesterol strongly attenuated the aggregation. Interestingly, aggregation was not observed for the structurally very closely related isoflavone, genistein. The extent of aggregation was nonlinearly dependent on the content of PI in egg phosphatidylcholine (eggPC) vesicles. The saturated dimyristoyl phospholipids, phosphatidylserine, phosphatidylcholine, phosphatidic acid, as well as phophatidylglycerol were also extensively aggregated by daidzein at 10 degrees C, i.e., below their main phase transition temperature whereas their aggregation at 35 degrees C in the fluid phase was strongly reduced. Vesicle aggregation could be accompanied by membrane fusion, however, neither contents mixing nor lipid mixing of the LUVs (large unilamellar vesicles) was observed in the presence of daidzein. Strong perturbation of the thermal phase behaviour of both dimyristoyl phosphatidylcholine (DMPC) and dimyristoyl phosphatidyls...Continue Reading

References

Oct 19, 1979·Biochimica Et Biophysica Acta·F OlsonD Papahadjopoulos
Apr 1, 1992·European Journal of Clinical Investigation·L SchweigererT Fotsis
Jan 1, 1992·Chemical & Pharmaceutical Bulletin·K Higashi, H Ogawara
May 18, 1991·Lancet·H P LeeN E Day
Jul 1, 1991·Biophysical Journal·M Roux, M Bloom
Jan 30, 1991·Biochimica Et Biophysica Acta·R C MacDonaldL R Hu
Feb 1, 1989·The Journal of Antibiotics·H OgawaraY Seoda
May 2, 1989·Biochemistry·H EllensJ Bentz
Nov 30, 1988·Biochemical and Biophysical Research Communications·A OkuraY Monden
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D F Sargent, R Schwyzer
Jul 30, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·H AdlercreutzT Hase
Jun 18, 1985·Biochemistry·H EllensF C Szoka
Jan 31, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·C BannwartH Adlercreutz
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T FotsisL Schweigerer
Nov 13, 1993·Lancet·H AdlercreutzS Watanabe
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W M Keung, B L Vallee
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·W M Keung, B L Vallee
Jan 1, 1986·Biophysical Journal·L G HerbetteD G Rhodes

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Citations

May 27, 2005·Life Sciences·Barbara Łania-PietrzakYoshiaki Shirataki
Jun 6, 2002·Chemistry and Physics of Lipids·Rumiana Koynova, Martin Caffrey
Jul 20, 2002·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Andrzej Boguslaw HendrichKrystyna Michalak
Feb 14, 2012·The Journal of Physical Chemistry. B·Mohit RaghunathanStephanie Tristram-Nagle
Feb 11, 2016·The Journal of Membrane Biology·Paulina StrugałaJanina Gabrielska
Dec 15, 2015·Biochimica Et Biophysica Acta·Evgeny G Chulkov, Olga S Ostroumova
Apr 5, 2016·Biochemistry Research International·Carlos Enrique Escárcega-GonzálezFrancisco A Posadas Del Rio
May 17, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Dalia SomjenFortune Kohen
Aug 4, 2010·Journal of Drug Targeting·Elena AppelDavid Mirelman
May 30, 2001·Journal of Drug Targeting·D G Fatouros, S G Antimisiaris
Apr 17, 2012·Biochimica Et Biophysica Acta·Bozena Pawlikowska-PawlegaWiesław I Gruszecki
Dec 6, 2014·Progress in Lipid Research·Stalin SelvarajUma Maheswari Krishnan
Sep 23, 2000·Electrophoresis·S K WiedmerM L Riekkola
Aug 3, 2002·CNS Drugs·Robert S Fisher, Jet Ho
Oct 17, 2019·Nanoscale Research Letters·Qiao WangYong Chen
May 27, 2017·International Journal of Biological Macromolecules·Shaqayeq RoqanianLeila Karami
Feb 9, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Mark J McVeyIvan H A Curran

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