Binding of Divalent Cations to Polygalacturonate: A Mechanism Driven by the Hydration Water

The Journal of Physical Chemistry. B
Uyen T D HuynhAli Assifaoui

Abstract

We have investigated the interactions between polygalacturonate (polyGal) and four divalent cations (M(2+) = Ba(2+), Ca(2+), Mg(2+), Zn(2+)) that differ in size and affinity for water. Our results evidence that M(2+)-polyGal interactions are intimately linked to the affinity of M(2+) for water. Mg(2+) interacts so strongly with water that it remains weakly bound to polyGal (polycondensation) by sharing water molecules from its first coordination shell with the carboxylate groups of polyGal. In contrast, the other cations form transient ionic pairs with polyGal by releasing preferentially one water molecule (for Zn(2+)) or two (for Ca(2+) and Ba(2+)), which corresponds to monodentate and bidentate binding modes with carboxylates, respectively. The mechanism for the binding of these three divalent cations to polyGal can be described by two steps: (i) monocomplexation and formation of point-like cross-links between polyGal chains (at low M(2+)/Gal molar ratios, R) and (ii) dimerization (at higher R). The threshold molar ratio, R*, between these two steps depends on the nature of divalent cations and is lower for calcium ions (R* < 0.1) than for zinc and barium ions (R* > 0.3). This difference may be explained by the intermediate a...Continue Reading

References

Aug 1, 1997·Quarterly Reviews of Biophysics·M G CacaceJ J Ramsden
Jul 17, 2001·Journal of Agricultural and Food Chemistry·P Cescutti, R Rizzo
Jun 6, 2002·Chemistry and Physics of Lipids·Hans Binder, Olaf Zschörnig
Apr 16, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sinjan De, Dennis Robinson
May 24, 2003·Biomaterials·LinShu LiuKevin B Hicks
Mar 15, 2005·Biomacromolecules·Ivan DonatiGudmund Skjåk-Braek
Dec 5, 2006·International Journal of Pharmaceutics·Kunihiko ItohDavid Attwood
Feb 13, 2007·Biomacromolecules·Liangbin LiEduardo Mendes
Feb 20, 2007·The Journal of Physical Chemistry. B·Yapeng FangLiangbin Li
May 16, 2009·Journal of Computational Chemistry·B R BrooksM Karplus
Sep 10, 2009·The Journal of Physical Chemistry. B·Ivan DonatiSergio Paoletti
Sep 23, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Eugenia Iskrenova-TchoukovaR James Kirkpatrick
Dec 1, 2010·Journal of Chemical Theory and Computation·Johnny C WuPengyu Ren
May 30, 2013·The Journal of Physical Chemistry. B·Massimiliano BorgognaIvan Donati
Aug 6, 2013·Carbohydrate Polymers·Irit VenturaHavazelet Bianco-Peled
Sep 16, 2014·The Journal of Physical Chemistry. B·Haohao FuChristophe Chipot
Apr 10, 2012·Journal of Chemical Theory and Computation·Olof AllnérAlessandra Villa

❮ Previous
Next ❯

Citations

Jan 21, 2020·Physical Chemistry Chemical Physics : PCCP·Aline Maire du PosetAdrien Lerbret
Apr 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Diana GawkowskaJustyna Cybulska
Oct 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·David C BassettPawel Sikorski
Nov 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Miete CelusMarc E Hendrickx
May 12, 2021·Journal of Molecular Recognition : JMR·Robert J FalconerAnthony K Mittermaier
Jun 13, 2018·Carbohydrate Polymers·Diana GawkowskaArtur Zdunek
Jun 26, 2021·Current Research in Food Science·Şerife ÜrüncüoğluVassilis Kontogiorgos
Jul 29, 2021·Physical Chemistry Chemical Physics : PCCP·Kimberly A Carter-FenkHeather C Allen
Feb 29, 2020·Biomacromolecules·Aline Maire du PosetAli Assifaoui
Aug 7, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Xuesong YiWenxin Shi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.