Binding of fibronectin and albumin to Enterococcus (Streptococcus) faecalis

Microbial Pathogenesis
P J Shorrock, P A Lambert

Abstract

Binding of human fibronectin (FN) and albumin to Enterococcus (Streptococcus) faecalis was investigated. Scatchard analysis showed that the cells could bind a maximum of 1300 molecules of FN with an association constant of 4.8 x 10(6) M-1. Binding did not appear to involve lipoteichoic acid. Heating the cells or pretreatment with protease or periodate reduced the binding, suggesting the involvement of protein and/or carbohydrate-containing components as the surface receptor. The cells could bind a maximum of 50,000 molecules of albumin but with a much lower affinity than FN (association constant 10.8 x 10(3) M-1). Surface hydrophobicity of E. faecalis was markedly decreased by albumin but not by FN.

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Citations

May 16, 2000·Veterinary Microbiology·M VanrobaeysP De Herdt
Feb 21, 2008·World Journal of Gastroenterology : WJG·Shugui WangYuan Kun Lee
May 25, 2005·International Endodontic Journal·G KayaogluD Ørstavik
Dec 28, 2002·Microbiological Research·Igor StyriakAsa Ljungh
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