PMID: 8948470Nov 13, 1996Paper

Binding of influenza A virus to monosialoganglioside (GM3) reconstituted in glucosylceramide and sphingomyelin membranes

Biochimica Et Biophysica Acta
T SatoY Okahata

Abstract

The binding of influenza A virus to GM3-containing monolayers at an air/water interface was quantitatively investigated by use of a quartz crystal microbalance (QCM). A QCM was horizontally attached to the monolayer from the air phase and the binding behavior of influenza virus was followed by the frequency changes of the QCM. GM3 was reconstituted in the momolayer of sphingomyelin (SM) or glucosylceramide (GlcCer). When the mole fraction of GM3 was below 30 mol%, the binding rate of the influenza A virus to the GM3/GlcCer membrane was significantly faster than that to GM3/SM membranes. When the mole fraction of GM3 in SM was below 20 mol%, specific binding of influenza virus was not observed at all. Binding of the virus to the GM3/GlcCer mixed membrane was inhibited by the addition of sialyllactose (Neu5Ac alpha 2-3Gal beta 1-4Glc). The virus binding was also visually observed by scanning electron microscopy. Viruses selectively bound to GM3/GlcCer (20:80, by mol%) membrane, but not to GM3/SM (20:80, by mol%) membrane. Furthermore, it was suggested that specific binding of influenza virus to the GM3/GlcCer membrane induced the changes in morphology of virus. It was clearly demonstrated that binding of influenza virus to GM3 wa...Continue Reading

References

Jan 1, 1994·Progress in Biophysics and Molecular Biology·B Maggio

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Citations

Dec 14, 2004·Analytical and Bioanalytical Chemistry·Yoshihisa Amano, Quan Cheng
Aug 22, 2007·Analytical and Bioanalytical Chemistry·Jie XuDavid S Gottfried
Jul 4, 2009·Journal of Receptor and Signal Transduction Research·Matthew A Cooper
Apr 20, 2016·Frontiers in Microbiology·Teruhiko MatsubaraToshinori Sato
Aug 30, 2011·Journal of Virological Methods·Ronghui WangYanbin Li
Jan 24, 2007·Journal of Molecular Recognition : JMR·Hideyuki MitomoYoshio Okahata
Dec 21, 2006·Chemical Biology & Drug Design·Hiroaki OkunoShinya Chiba
Aug 6, 2005·Clinical Chemistry·Benjamin GodberMatthew A Cooper
Jul 8, 1999·The Journal of Nutrition·H VesperA H Merrill
Mar 13, 2008·Science and Technology of Advanced Materials·Mohamad M Ayad, Eman A Zaki
Jun 30, 2009·Journal of Medicinal Chemistry·Teruhiko MatsubaraToshinori Sato
Jul 31, 2007·Journal of the American Chemical Society·Nam-Joon ChoCurtis W Frank

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