PMID: 9165303Jan 1, 1997Paper

Binding of iron to neuromelanin of human substantia nigra and synthetic melanin: an electron paramagnetic resonance spectroscopy study

Free Radical Biology & Medicine
T ShimaL Zecca

Abstract

The binding of iron by melanin is a potentially important phenomenon as detailed knowledge of this binding is essential for understanding the role of melanin and iron in the pathogenesis of oxidative damage in the substantia nigra. Electron paramagnetic resonance spectroscopy is one of the most useful approaches in the investigation of melanins and their interaction with iron. This study was undertaken to obtain systematic data on the effects of ferric iron on the electron paramagnetic resonance spectra of neuromelanin and synthetic models of neuromelanin. Data from the latter can potentially be used to infer as to the state of neuromelanin in the human substantia nigra. The results of this study indicate that the spectra at g = 4.3, attributable to Fe3+, provides a useful parameter for determining the amount of paramagnetic iron bound to melanin. These data together with the magnitude of the free radical signal from melanin provides an indication of the amount of iron bound to neuromelanin in intact human substantia nigra. After binding to melanin, the iron can change its location and/or state, which is indicated by the change in the microwave power saturation that occurs gradually after the binding of the iron. At least part ...Continue Reading

References

Sep 1, 1992·Journal of Neurochemistry·K JellingerM B Youdim
Jan 1, 1992·Annals of Neurology·H M SwartzL Zecca
Mar 1, 1991·Journal of Neurochemistry·E SoficM B Youdim
Jan 16, 1992·Biochimica Et Biophysica Acta·L ZeccaE Parati
Sep 30, 1991·Neuroscience Letters·K WakamatsuT Nagatsu
Sep 23, 1991·Biochimica Et Biophysica Acta·R CarstamE Rosengren
Nov 1, 1991·Journal of Neurochemistry·D Ben-ShacharM B Youdim
Feb 1, 1989·Journal of Neurochemistry·P RiedererM B Youdim
Jul 1, 1967·Journal of Neurochemistry·M H Van WoertD C Borg
Jul 1, 1969·Journal of Neuropathology and Experimental Neurology·H Barden
Aug 1, 1984·Archives of Biochemistry and Biophysics·T Sarna, R C Sealy
Feb 1, 1983·Mechanisms of Ageing and Development·D M Mann, P O Yates
Mar 20, 1981·The Journal of Comparative Neurology·B Bogerts
Jan 1, 1993·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·L Zecca, H M Swartz
Oct 1, 1958·Journal of Neuropathology and Experimental Neurology·J M FOLEY, D BAXTER
Oct 1, 1958·Journal of Neurochemistry·B HALLGREN, P SOURANDER

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Citations

Sep 15, 2004·Cell and Tissue Research·Daniela BergPeter Riederer
Aug 9, 2003·Biochemical Pharmacology·Kay L DoubleDorit Ben-Shachar
Aug 30, 2002·Neurotoxicology and Teratology·K L DoubleM Gerlach
Jun 22, 2007·The Journal of Physical Chemistry. B·Lian Hong, John D Simon
Nov 10, 2001·Annual Review of Phytopathology·Joan M HensonAlan W Day
Oct 25, 2013·Neurotoxicity Research·Fabio A ZuccaLuigi Zecca
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Luigi ZeccaFabio A Zucca
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·D SulzerL Zecca
Aug 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Luca TurinAndrew P Horsfield
Dec 20, 2014·Bioinorganic Chemistry and Applications·Paweł Ramos, Barbara Pilawa
Nov 13, 2012·Applied Magnetic Resonance·Magdalena ZdybelZdzisław Kruczyński
Nov 1, 2012·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Emanuele FerrariLuigi Casella
Aug 5, 2008·Neurobiology of Disease·Shannon L Rhodes, Beate Ritz
Nov 16, 2004·Pigment Cell Research·Fabio A ZuccaLuigi Zecca
May 14, 2004·Pigment Cell Research·Yan LiuJohn D Simon
Apr 24, 2004·Annals of the New York Academy of Sciences·Mario E GötzPeter Riederer
Oct 13, 2015·Progress in Neurobiology·Fabio A ZuccaLuigi Zecca
Sep 30, 2006·Chemistry : a European Journal·Alejandro González OriveRoberto C Salvarezza
Nov 11, 2005·Pigment Cell Research·Albert R Wielgus, Tadeusz Sarna
May 29, 2013·Pigment Cell & Melanoma Research·Marco d'IschiaShosuke Ito
Aug 14, 2012·Pigment Cell & Melanoma Research·Patrycja KaczaraJanice M Burke
Nov 7, 2006·Pigment Cell Research·Paul Meredith, Tadeusz Sarna
Feb 20, 2014·Journal of Neurochemistry·Juan Segura-AguilarFabio A Zucca
Feb 8, 2014·Ageing Research Reviews·Amy ReeveDoug Turnbull
Feb 4, 2014·Neurotoxicology·Ana M Espinosa-OlivaAlberto Machado
Jan 15, 2015·Journal of Neuroinflammation·Nikenza ViceconteJosé L Venero
Mar 4, 2000·Biochimica Et Biophysica Acta·L LopianoM Fasano
Dec 13, 2005·Free Radical Biology & Medicine·Mariusz ZarebaJanice M Burke
Jul 17, 2016·Radiation Protection Dosimetry·Bernard Gallez
May 4, 2017·The International Journal of Neuroscience·Antonio Martin-BastidaPaola Piccini
Jun 7, 2006·Journal of Neural Transmission·K L Double
Mar 29, 2000·Journal of Neurochemistry·L ZeccaS Sonnino

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