PMID: 3768402Nov 14, 1986Paper

Binding of lysophosphatidylcholine to the rat liver fatty acid binding protein

Biochimica Et Biophysica Acta
R E Burrier, P Brecher

Abstract

In this study, lysophosphatidylcholine (lysoPC) was shown to bind to a fatty acid binding protein isolated from rat liver. To demonstrate the binding, lysoPC was incorporated into multilamellar liposomes and incubated with protein. For comparison, binding of both lysoPC and fatty acid to liver fatty acid binding protein, albumin, and heart fatty acid binding protein were measured. At conditions where palmitic acid bound to liver fatty acid binding protein and albumin at ligand to protein molar ratios of 2:1 and 5:1, respectively, lysoPC binding occurred at molar ratios of 0.4:1 and 1:1. LysoPC did not bind to heart fatty acid binding protein under conditions where fatty acid bound at a molar ratio of 2:1. Competition experiments between lysoPC and fatty acid to liver fatty acid binding protein indicated separate binding sites for each ligand. An equilibrium dialysis cell was used to demonstrate that liver fatty acid binding protein was capable of transporting lysoPC from liposomes to rat liver microsomes, thereby facilitating its metabolism. These studies suggest that liver fatty acid binding protein may be involved in the intracellular metabolism of lysoPC as well as fatty acids, and that functional differences may exist betwe...Continue Reading

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Citations

Dec 1, 1994·Cancer Metastasis Reviews·S Sorof
Jun 15, 1990·Experientia·R M KaikausR K Ockner
Jun 17, 2000·Biochimica Et Biophysica Acta·J Storch, A E Thumser
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·S H Khan, S Sorof
Jun 15, 2010·Biochimica Et Biophysica Acta·Eduardo De GerónimoBetina Córsico
Jan 4, 1988·European Journal of Biochemistry·H Schulenberg-SchellF Spener
Dec 24, 2005·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Tetsuo KawamuraToshimitsu Suzuki
Oct 1, 1993·Journal of Cellular Physiology·T Keler, S Sorof
Feb 22, 2005·The Journal of Biological Chemistry·Tony VelkovMartin J Scanlon
Nov 27, 1987·Biochimica Et Biophysica Acta·M AngelicoA Cantafora
Jun 23, 1987·Biochimica Et Biophysica Acta·R E BurrierP Brecher
Jan 1, 1989·Progress in Lipid Research·V MatareseD A Bernlohr
Jan 4, 1991·Biochimica Et Biophysica Acta·J H VeerkampR G Maatman
Dec 9, 1994·Biochimica Et Biophysica Acta·P Moreau, C Cassagne
Dec 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J H VeerkampC F Prinsen
Aug 1, 1988·Archives of Biochemistry and Biophysics·R J PaulussenJ H Veerkamp

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