PMID: 1195110Nov 1, 1975Paper

Binding of metronidazole and its derivatives to plasma proteins: an assessment of drug binding phenomenon

Journal of Pharmaceutical Sciences
D R SanvordekerH J Lambert

Abstract

Metronidazole and four derivatives were studied in vitro to investigate the differences in the extent of their binding to plasma proteins. Modification at the terminal portion of the alkyl side chain resulted in wide differences in the extent of binding. Molecular orbital calculations were performed by the CNDO and MINDO/2 methods to estimate the frontier electron density on the hetero atom at the 3'-position of the alkyl side chain. A linear correlation between the protein binding parameter (loge P) and the frontier electron density (qr) was observed for the binding of this group of trichomonicidal drugs. NMR spectroscopy was used to demonstrate that the alkyl side chain participated in the binding of these compounds to plasma proteins.

Citations

Jan 1, 1983·European Journal of Clinical Pharmacology·I AmonF Nagel
Jul 1, 1985·European Journal of Drug Metabolism and Pharmacokinetics·H AllarsR S Norton
Jun 22, 2011·Chemical Communications : Chem Comm·Xiaohui WangZijian Guo
Sep 1, 1976·Journal of Pharmaceutical Sciences·Y W ChienL C Tao
Aug 1, 1976·Journal of Pharmaceutical Sciences·F W Goodhart, M L Eichman
Jan 14, 2005·Journal of Clinical Pharmacology·Odin J NadererPhilip C Smith
Aug 1, 1984·British Journal of Clinical Pharmacology·B DiquetP Viars
Jan 1, 1983·Teratogenesis, Carcinogenesis, and Mutagenesis·G L BiagiP A Borea
Jan 1, 1983·Teratogenesis, Carcinogenesis, and Mutagenesis·G Cantelli-FortiG L Biagi
Oct 19, 2019·Journal of Hazardous Materials·Sufia HenaJean-Philippe Croué
Apr 1, 1977·Journal of Pharmaceutical Sciences·J J Vallner

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