PMID: 9537027Jan 1, 1980Paper

Binding of murine myeloma proteins of different Ig classes and subclasses to Fc-reactive surface structures in gram-positive cocci

Scandinavian Journal of Immunology
E Myhre, G Kronvall

Abstract

Twelve different murine myeloma proteins were tested for binding to seventy Gram-positive strains belonging to group A, C and G streptococci and to Staphylococcus aureus. Group A streptococci, known to bind human IgG, were incapable of binding any of eight murine IgG immunoglobulins tested except for one strain that bound an IgG2b myeloma protein. In contrast, group C and G streptococci interacted with murine immunoglobulins of subclasses IgG2a, IgG2b and IgG3, and G strains also to a lesser extent with IgG1. Bovine and equine-group C streptococci did not differ from human group C streptococci in their IgG reactivity. Staphylococcal strains showed a high reactivity with murine myeloma components of IgG subclasses 2a, 2b and 3 and a low but definite binding of an IgG1 myeloma protein. IgA myeloma protein S-122 interacted with nine of fifteen group A streptococci. This binding could not be inhibited by human IgG and the reactivity is thus different from Fc-mediated binding of immunoglobulins. One of three IgA myeloma proteins tested, TEPC 15, bound to staphylococci. The Fc specificity of this interaction was confirmed by chromatography on protein A-Sepharose and by inhibition studies using polyclonal human IgG. The protein A reac...Continue Reading

References

Jan 1, 1978·Scandinavian Journal of Immunology·M R MacKenzieN L Warner
Jan 1, 1978·Journal of Immunological Methods·J P BrownI Hellström
May 18, 1977·Medical Microbiology and Immunology·H BrunnerH G Schiefer
Jan 1, 1976·Scandinavian Journal of Immunology·E Saltvedt, M Harboe
Jan 1, 1966·International Archives of Allergy and Applied Immunology·P J McConahey, F J Dixon
Jan 1, 1974·Scandinavian Journal of Immunology·M Harboe, I Fölling
Jul 1, 1972·Physiological Reviews·M Potter

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Citations

Apr 9, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·L A BurovaA A Totolian
Jan 1, 1994·DNA Sequence : the Journal of DNA Sequencing and Mapping·J P MurphyC J Duggleby
Dec 1, 1986·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·M ErntellG Kronvall

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