PMID: 7023645Mar 15, 1981Paper

Binding of N-nitroso carcinogens in pancreatic tissue

Cancer
P V Woolley, S D Pinsky

Abstract

Carcinoma of the pancreas can be produced in guinea pigs by the oral administration of 1-methyl-1-nitrosourea (MNU). Our present studies have examined the distribution of this compound in these animals following parenteral and oral administration and also its specific sites of binding within the pancreatic cell. Emphasis has been placed upon the comparison of the uptake and binding of MNU with the related compound 1-methyl-3-nitro-1-nitrosoguanidine (MNNG), which does not seem to be carcinogenic to the pancreas after oral administration. The distribution data indicate uptake into pancreas that is comparable to that of other organs. Binding data show both MNU and MNNG to extensively modify subcellular organelles and the DNA and proteins of chromatin, but that MNU does this to a somewhat greater extent than MNNG.

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Citations

Sep 1, 1984·The Journal of Surgical Research·F E JohnsonD R Herbold
Sep 1, 1987·Mutation Research·J B Guttenplan
Jun 1, 1995·Mutation Research·R H Liu, J H Hotchkiss
Feb 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D W CraginT Shibamoto
May 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H BiaudetG Debry
Dec 1, 1994·Toxicology in Vitro : an International Journal Published in Association with BIBRA·S Y Brendler-SchwaabB L Pool-Zobel
Jan 1, 1989·Free Radical Biology & Medicine·H BartschC Malaveille
Feb 1, 1985·British Journal of Industrial Medicine·J E VenaR E Barnes

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