PMID: 8988533Nov 1, 1996Paper

Binding of peptides naturally presented by HLA-B27 to the differentially disease-associated B*2704 and B*2706 subtypes, and to mutants mimicking their polymorphism

Tissue Antigens
B GalochaJ A López de Castro

Abstract

B*2704 and B*2706 are closely related HLA-B27 subtypes of which the former but not the latter is associated to ankylosing spondylitis. Their peptide specificity relative to other disease-associated subtypes was analyzed by testing binding of self-peptides naturally presented by B*2705 or B*2702, and synthetic analogs, to B*2704, B*2706, and site-specific mutants mimicking their changes. Peptides with basic, aliphatic or aromatic C-terminal residues bound to B*2705 with similar affinity. In B*2704 C-terminal aliphatic/ aromatic residues were preferred. B*2706 discriminated drastically between polar and nonpolar C-terminal residues, showing strong preference for Leu and Phe, and less than B*2704 for basic and Tyr residues. Loss of single acidic charges (D > S77, D > Y116) increased preference for C-terminal Leu and Phe, but allowed efficient binding of peptides with basic residues or Tyr. Their gain (V > E152, H > D114) maintained wide C-terminal specificity, but severely impaired binding, presumably by disrupting interactions with internal peptide residues. This was compensated by Y116 in the double D114Y116 mutant. The specificity of B*2704 and B*2706 was explained only partially by the separate effects of single mutations, ind...Continue Reading

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Citations

Oct 31, 1998·Journal of Peptide Science : an Official Publication of the European Peptide Society·S KrebsD Rognan
Apr 2, 1998·Current Opinion in Immunology·J A López de Castro
Dec 29, 1998·Molecular Medicine Today·C López-LarreaJ Martinez-Borra
Jul 28, 1999·Protein Science : a Publication of the Protein Society·S KrebsJ A López de Castro
Aug 18, 1999·Immunological Reviews·J D TaurogR E Hammer
Dec 21, 2000·Current Rheumatology Reports·M MartíJ A López de Castro
Dec 1, 2001·Modern Rheumatology·N K Mehra, U Kanga
Mar 11, 1999·Journal of Receptor and Signal Transduction Research·S DédierD Rognan
Oct 1, 2014·PloS One·Alejandro BarrigaDaniel López
Jul 18, 2002·The Journal of Biological Chemistry·Manuel RamosJosé A López de Castro
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Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C J LuckeyV H Engelhard
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura SesmaJosé A López de Castro
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·A ParadelaJ A López De Castro
Oct 24, 2001·The Journal of Biological Chemistry·I AlvarezJ A López de Castro
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M García-PeydróJ A Castro

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