Binding of platelet factor 4 to cultured human umbilical vein endothelial cells

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Binding of platelet factor 4 to cultured human umbilical vein endothelial cells

Abstract

References

The release, distribution, and clearance of human beta-thromboglobulin and platelet factor 4

Demonstration of a platelet enzyme, degrading heparan sulphate

The anticoagulant effect of heparan sulfate and dermatan sulfate

Effect of a platelet endoglycosidase on cell surface associated heparan sulphate of human culturei endothelial and glial cells

The identification and localization of antithrombin III in human tissues

Antithrombin III in fresh and cultured human endothelial cells: a natural anticoagulant from the vascular endothelium

Platelet antiheparin proteins and antithrombin III interact with different binding sites on heparin molecule

Binding of heparin on the surface of cultured human endothelial cells

Inhibition of thrombin by antithrombin III in the presence of certain glycosaminoglycans found in the mammalian aorta

Correlation of sulfate content and degree of carboxylation of heparin and related glycosaminoglycans with anticomplement activity. Relationships to the anticoagulant and platelet-aggregating activities

Anticoagulant activity of heparin: separation of high-activity and low-activity heparin species by affinity chromatography on immobilized antithrombin

Coupling of glycosaminoglycans to agarose beads (sepharose 4B)

Sulfated mucopolysaccharide synthesis and secretion in endothelial cell cultures

Anticoagulant activity of human arterial mucopolysaccharides

Preparation of iodine-131 labelled human growth hormone of high specific activity

The relationship of heparin activity to platelet concentration

Citations

Effect of the heparinoid pentosan polysulphate (SP 54) on the functional properties of cultured bovine aortic endothelial cells

The in vivo release of human platelet factor 4 by heparin

Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes

The transfer of platelet factor 4 from its proteoglycan carrier to natural and synthetic polymers

Platelet factor 4 binding to glomerular microvascular matrix

Interaction of platelet factor 4 with human platelets

Ophidian envenomation strategies and the role of purines

Von Willebrand factor, a key protein in the exposure of CD62P on platelets

Heparin-induced thrombocytopenia

PF4 inhibits thrombin-stimulated MMP-1 and MMP-3 metalloproteinase expression in human vascular endothelial cells

Heparin-induced thrombocytopenia and thrombosis

Molecular defects in interactions of platelets with the vessel wall

Selective targeting of gene products with the megakaryocyte platelet factor 4 promoter

Interactions of thrombospondin with endothelial cells: receptor-mediated binding and degradation

Thrombospondin modulates focal adhesions in endothelial cells

The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation

Human endothelial cells stimulate leukotriene synthesis and convert granulocyte released leukotriene A4 into leukotrienes B4, C4, D4 and E4

Platelet aggregability in patients with a VVI pacemaker

Differences in binding of platelet factor 4 to vascular endothelium in vivo and endothelial cells in vitro

Involvement of cell surface heparin sulfate in the binding of lipoprotein lipase to cultured bovine endothelial cells

Identification in vitro of an endothelial cell surface cofactor for antithrombin III. Parallel studies with isolated perfused rat hearts and microcarrier cultures of bovine endothelium

Plasma clearance of human extracellular-superoxide dismutase C in rabbits

Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells

Role of the GRO family of chemokines in monocyte adhesion to MM-LDL-stimulated endothelium

Polycistronic expression of human platelet factor 4 with heparin-neutralizing activity in Escherichia coli

NHLBI state of the science symposium in therapeutic apheresis: Knowledge gaps and research opportunities in the area of hematology-oncology

Binding of platelet factor four (PF 4) to glomerular polyanion

The role of the CXC chemokines platelet factor-4 (CXCL4/PF-4) and its variant (CXCL4L1/PF-4var) in inflammation, angiogenesis and cancer

Plasma levels of platelet secretory proteins

Inhibitory effect of platelet factor 4 on human erythroleukemic cells is dependent on cell surface heparan sulfate

Improved method for purification of human platelet factor 4 by affinity and ion-exchange chromatography

Contribution of thrombogenic factors to the pathogenesis of atherosclerosis

Low-affinity heparin potentiates the action of high-affinity heparin oligosaccharides

Anticoagulant effects of a low molecular weight heparinoid (Org 10172) in human volunteers and haemodialysis patients

The influence of physical exercise and intravenous heparin on plasmatic concentration of platelet factor 4 in young survivors of myocardial infarction

Human platelet factor 4 and protamine sulphate interaction with glycosaminoglycans in the rabbit

The interaction of platelets with cultured cells

Platelet factor 4 neutralizes heparan sulfate-enhanced antithrombin inactivation of factor Xa by preventing interaction(s) of enzyme with polysaccharide

Heparin-independent, PF4-dependent binding of HIT antibodies to platelets: implications for HIT pathogenesis.

Rational design and characterization of platelet factor 4 antagonists for the study of heparin-induced thrombocytopenia.

Pathophysiology of antithrombin III deficiency

Role of monocytes and endothelial cells in heparin-induced thrombocytopenia

Influence of platelet factor 4 on the neutralization of heparin by protamine

Human platelet factor 4 monomer-dimer-tetramer equilibria investigated by 1H NMR spectroscopy

Low-affinity platelet factor 4 1H NMR derived aggregate equilibria indicate a physiologic preference for monomers over dimers and tetramers.

Evidence for an endothelial cell dysfunction in association with Behçet's disease

Platelet function, platelet prostanoids and vascular prostacyclin in diabetes mellitus.

Chemistry, measurement, and clinical significance of platelet specific proteins

Two populations of endothelial cell antibodies cross-react with heparin

Exposure of fibrinogen-adherent platelets to plasma proteins: a new method for studying protein interactions with platelets

Related Concepts

Related Feeds

Blood Clotting Disorders

Related Papers

Influence of human beta-thromboglobulin on prostaglandin production by pig aortic endothelial cells in culture

Hierarchical self-assembly of surfactant-encapsulated and organically grafted polyoxometalate complexes

Disappearance of human platelet factor 4 (PF4) in rabbits: does an immediate component exist?

The carboxyl-terminal tridecapeptide of platelet factor 4 is a potent chemotactic agent for monocytes

Human platelet factor 4: preparation from outdated platelet concentrates and application in cerebral vascular disease