Binding of serum prostate antigen to concanavalin A in patients with cancer or hyperplasia of the prostate.

Oncology
M BarakN Gruener

Abstract

The percentage of nonglycosylated prostate-specific antigen (PSA) was measured in the serum of 15 prostate cancer patients and 15 patients with benign hyperplasia of the prostate. The larger part of serum PSA in both groups was glycosylated, but while in carcinoma of the prostate the mean percentage of nonglycosylated PSA was 38.4 +/- 6.5, in benign prostate hyperplasia (BPH) only a mean of 14.2 +/- 4.3% of the PSA was nonglycosylated. These significantly higher results (p less than 0.001) suggest a different pattern of release of PSA from cancer cells and from hyperplastic or normal cells. Since in a part of the BPH we encounter elevations of PSA similar to the levels found in neoplasms, the degree of concanavalin A binding can provide an additional means in differentiating between benign and malignant lesions.

Citations

Jan 1, 1994·Journal of Clinical Laboratory Analysis·J T Wu
Jan 1, 1995·Journal of Clinical Laboratory Analysis·J T WuJ T Colemere
Jul 18, 1992·Lancet·J van Pelt, M P van Dieijen-Visser
Jul 10, 2003·Clinical Biochemistry·Pranab S BasuSandip K Batabyal
Mar 18, 1999·Social Science & Medicine·C L NekolaichukT O Maguire
Jan 31, 2002·Journal of Chromatography. B, Biomedical Sciences and Applications·S SumiK Yoshida
Nov 28, 2008·Journal of Proteome Research·Danni L MeanyDaniel W Chan
Jan 16, 1998·Journal of Advanced Nursing·J DysonD Forman
Feb 1, 1997·Journal of Advanced Nursing·J Kylmä, K Vehviläinen-Julkunen
Aug 11, 2015·Colloids and Surfaces. B, Biointerfaces·Neslihan IdilAdil Denizli
Jun 23, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tijl VermassenJoris R Delanghe

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