Binding of several benzodiazepines to bovine serum albumin: Fluorescence study

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Roberta G MachicoteLiliana Bruzzone

Abstract

The interactions of lorazepam, oxazepam and bromazepam with bovine serum albumin (BSA) were studied by fluorescence spectrometry. The Stern-Volmer quenching constants and corresponding thermodynamic parameters DeltaH, DeltaG and DeltaS were calculated. The binding constants and the number of binding sites were also investigated. The distances between the donor (BSA) and the acceptors (benzodiazepines) were obtained according to fluorescence resonance energy transfer and conformational changes of BSA were observed from synchronous fluorescence spectra.

References

Jan 15, 2005·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Shuyun BiHanqi Zhang
Jun 6, 2009·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Hui CaoMing Xu
Sep 5, 2009·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Xiao-Le HanRan Li
Sep 25, 2009·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Fengling CuiYan Lu
Sep 29, 2009·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Jianbo XiaoChunxi Liu
Dec 17, 2009·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Yongnian NiSerge Kokot

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Citations

Dec 2, 2011·Journal of Photochemistry and Photobiology. B, Biology·E AlarcónE A Lissi
Oct 26, 2011·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mijun PengYuping Zhang
Nov 8, 2011·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Nahid Shahabadi, Mahnaz Mohammadpour
Dec 18, 2010·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Yongnian NiSerge Kokot
Jul 25, 2012·Luminescence : the Journal of Biological and Chemical Luminescence·Xue-Hong ZhangCui-Wu Lin
Jun 14, 2014·Luminescence : the Journal of Biological and Chemical Luminescence·Xuehong ZhangCuiwu Lin
Jun 19, 2012·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Ruiyong WangJunbiao Chang
Sep 25, 2017·European Biophysics Journal : EBJ·Aleksandra PavićevićMiloš Mojović
Jan 30, 2020·Luminescence : the Journal of Biological and Chemical Luminescence·Said Abd El-Monem HassanNadia Fayek Youssef
Jan 18, 2020·Journal of the American Chemical Society·Yaning WangSanzhong Luo

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