PMID: 6161972Feb 1, 1981Paper

Binding of wheat gliadin in vitro to reticulum in normal and dermatitis herpetiformis skin

The Journal of Investigative Dermatology
D J UnsworthE J Holborow

Abstract

We have demonstrated by indirect immunofluorescence that wheat gliadin binds in vitro to reticulin-like fibrils present in cryostat sections of human skin, and rat liver, kidney and stomach. Gliadin was seen to bind to fibrils throughout the dermis of both normal and dermatitis herpetiformis skin, and this was particularly striking in the dermal papillae. Serum from 2 dermatitis herpetiformis patients who did not have antireticulin antibody gave reticulin staining when retested by immunofluorescence on cryostat sections of rat tissue pretreated with gliadin. Gliadin treated sections may prove useful in screening patients with gluten sensitive enteropathy for anti-gliadin antibody. Binding of gliadin to skin sites in dermatitis herpetiformis patients and subsequent deposition of antigliadin antibody at these sites may be involved in the development of skin lesions.

Citations

Jan 1, 1987·Archives of Dermatological Research·D J UnsworthL Fry
Dec 1, 1981·The British Journal of Dermatology·D J UnsworthL Fry
Nov 1, 1981·Archives of Disease in Childhood·D J UnsworthE J Holborow
Nov 16, 2004·Arquivos De Gastroenterologia·Shirley Ramos da Rosa UtiyamaLorete Maria da Silva Kotze
Dec 1, 1990·International Journal of Dermatology·J B van der Meer
Jul 1, 1986·Clinical and Experimental Dermatology·P D MauriceW G Reeves
Jun 1, 1981·Journal of the Royal Society of Medicine·A F SwainD J Unsworth
Jan 1, 1986·Archives of Dermatological Research·L M SollidP Brandtzaeg
Oct 1, 1984·The British Journal of Dermatology·T P ChorzelskiA Kapuscinska
Jan 1, 1983·Annals of the New York Academy of Sciences·T P ChorzelskiV Kumar
Jun 1, 1984·Scandinavian Journal of Dental Research·J Hietanen, T Reunala
May 1, 1983·The Journal of Investigative Dermatology·A T LaneW L Weston
Feb 1, 1982·Journal of the American Academy of Dermatology·C M Lapiere

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