PMID: 6142724Apr 1, 1984

Binding potencies of 3 new beta 2 specific blockers to beta receptors in the ciliary processes and the possible relevance of these drugs to intraocular pressure control

The British Journal of Ophthalmology
G E Trope, B Clark

Abstract

The binding potencies of 3 new beta 2 blocking drugs to beta receptors in the ciliary processes were studied by means of radioligand techniques. The drugs studied were IPS339, ICI118,551, and Sandoz L1 32-468. The order of potency of these drugs was IPS339 greater than Sandoz L1 32-468 greater than ICI118,551. The beta 2 dissociation constants (KDs) for these drugs were 0.90 nM, 6.60 nM, and 55 nM respectively. These results are compared with those for other adrenergic agents, including timolol. The potential role of topical beta 2 blockers in glaucoma is discussed.

References

Jan 1, 1979·The British Journal of Ophthalmology·S E SmithV B Whitmarsh
Jul 1, 1982·The New England Journal of Medicine·H J Motulsky, P A Insel
Dec 1, 1982·The British Journal of Ophthalmology·G E Trope, B Clark
May 1, 1980·Ophthalmology·E M Van Buskirk

Citations

Jan 1, 1985·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·B ClarkS J Titinchi
Jan 1, 1989·Pharmacology & Therapeutics·M F Sugrue
Jan 1, 1990·Annals of the New York Academy of Sciences·M L Kirby

Related Concepts

IPS 339, monohydrochloride, (+-)-isomer
ICI 118551, hydrochloride
4-(3-tert-butylamino-2-hydroxypropoxy)spiro(cyclohexane-1,2-indan)-1-one
Adrenergic beta-Antagonists
Ciliary Body
Glaucoma, Open-Angle
Propanolamines
Radioligand Assay
Beta-adrenergic receptor
Dall Sheep

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