Binding profile of spiramycin to oviducal proteins of laying hens

Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine
N Furusawa

Abstract

In vitro protein binding of spiramycin (SP) in the plasma and oviducts of laying hens was studied. The data for SP were compared with those for oxytetracycline (OTC), sulphadimidine (SDD), sulphamonomethoxine (SMM) and sulphaquinoxaline (SQ). The two oviduct segments, magnum (M) and isthmus plus shell gland (IS), were collected. The soluble (cell sap) fractions from the magnum (M-S9) and the isthmus plus shell gland (IS-S9) were used as samples. Plasma protein binding was highest for SQ (81.4%) (P < 0.01), and lowest for SDD (30.9%) (P < 0.01). No M-S9 protein binding of OTC was found. The IS-S9 protein binding of SP (60.4%) was very much higher than those of OTC (0.8%), SDD (4.1%), SMM (4.0%) and SQ (12.3%) (P < 0.01). Biological half-lives of these drugs in egg albumen were directly correlated to the extent of their binding to IS proteins. Of plasma, M-S9 and IS-S9, variation in SP concentration in the ranges from 1 to 20 micrograms/ml did not alter the binding properties of the drug.

References

Jul 1, 1978·Acta Pharmacologica Et Toxicologica·O Ladefoged
Dec 1, 1992·Clinical Pharmacokinetics·G M Pacifici, A Viani
Sep 1, 1990·British Poultry Science·B Roudaut, J P Moretain
Jan 1, 1968·Antibiotica Et Chemotherapia. Fortschritte. Advances. Progrès·T Struller
Jan 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·B T DoumasH G Biggs
Oct 1, 1982·Journal of Pharmacokinetics and Biopharmaceutics·R F BevillD W Bourne
Mar 21, 1998·Journal of Veterinary Pharmacology and Therapeutics·D S SonE Kokue
Jul 3, 1998·British Poultry Science·N FurusawaH Yamaguchi

Citations

Mar 15, 2014·PLoS Computational Biology·Lars Ole SchwenLars Kuepfer
Jan 15, 2016·Journal of Veterinary Pharmacology and Therapeutics·G J Schefferlie, P Hekman
Nov 7, 2006·Journal of Veterinary Pharmacology and Therapeutics·M VoermansJ M Ensink

Related Concepts

Microbicides
Antibiotics
Alpha 1-Acid Glycoprotein (Acute Phase)
Ovalbumin
Animal Oviduct
Oxytetracycline, (5 beta)-Isomer
Plasma Protein Binding Capacity
Sulfamethazine
Sulfamonomethoxine
Sulfaquinoxaline

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