Binding site for basic drugs on alpha 1-acid glycoprotein as revealed by chemometric analysis of biochromatographic data

Biomedical Chromatography : BMC
R KaliszanM Turowski

Abstract

Interactions between alpha 1-acid glycoprotein (AGP) and 52 basic drugs were quantified by means of high-performance liquid chromatography (HPLC). The HPLC retention parameters were related quantitatively to the hydrophobicity and molecular modelling parameters, giving rise to the prediction of relative drug-AGP binding from the chemical structure of a drug. A structural model of one binding site on AGP, common for various classes of drugs, was defined which accounted for the observed and reported differences in binding to AGP. A combination of biochromatography and chemometrics has been presented as a promising new approach in biochemical/pharmacological studies.

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Citations

Jul 17, 1998·Biomedical Chromatography : BMC·M Turowski, R Kaliszan
Dec 11, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ryan MatsudaDavid S Hage
Apr 10, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Michal Markuszewski, Roman Kaliszan
Feb 7, 2003·SAR and QSAR in Environmental Research·P GramaticaE Papa
Feb 5, 2013·Journal of Chromatographic Science·Cen ChenWen Xiao
May 8, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Marios ChrysanthakopoulosAnna Tsantili-Kakoulidou
Aug 10, 2001·Drug Metabolism Reviews·Z H Israili, P G Dayton
Mar 7, 2013·Expert Opinion on Drug Discovery·Theodosia VallianatouAnna Tsantili-Kakoulidou
Dec 27, 2005·Analytical Biochemistry·Nariyasu ManoJunichi Goto
Sep 23, 2006·Annals of Tropical Medicine and Parasitology·G O GbotoshoL A Salako
Dec 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Saeed TaheriGary R Strichartz
Jul 1, 2011·Analytical Methods : Advancing Methods and Applications·David S HageXiwei Zheng
Oct 9, 2008·The Journal of Physical Chemistry. B·Bridget A Becker, Cynthia K Larive
Apr 10, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·David S Hage
Nov 6, 2003·Journal of the American Chemical Society·Maciej TurowskiEdward R Thornton

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