Binding Strength of Gram-Positive Bacterial Adhesins

Frontiers in Microbiology
Yves F Dufrêne, Albertus Viljoen

Abstract

Bacterial pathogens are equipped with specialized surface-exposed proteins that bind strongly to ligands on host tissues and biomaterials. These adhesins play critical roles during infection, especially during the early step of adhesion where the cells are exposed to physical stress. Recent single-molecule experiments have shown that staphylococci interact with their ligands through a wide diversity of mechanosensitive molecular mechanisms. Adhesin-ligand interactions are activated by tensile force and can be ten times stronger than classical non-covalent biological bonds. Overall these studies demonstrate that Gram-positive adhesins feature unusual stress-dependent molecular interactions, which play essential roles during bacterial colonization and dissemination. With an increasing prevalence of multidrug resistant infections caused by Staphylococcus aureus and Staphylococcus epidermidis, chemotherapeutic targeting of adhesins offers an innovative alternative to antibiotics.

References

May 1, 1995·Journal of Dental Research·A PrakobpholS J Fisher
Jan 1, 1994·Annual Review of Microbiology·J M PattiM Höök
Feb 26, 1999·Trends in Microbiology·T J Foster, M Höök
Oct 24, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yasser BustanjiBruno Samorí
Dec 3, 2005·Nature Reviews. Microbiology·Timothy J Foster
Apr 22, 2006·Nature Methods·Peter Hinterdorfer, Yves F Dufrêne
Nov 29, 2007·Pflügers Archiv : European journal of physiology·David AlsteensYves F Dufrêne
Jun 25, 2008·Annual Review of Biophysics·Wendy E ThomasEvgeni Sokurenko
Oct 16, 2008·Cell Host & Microbe·Evgeni V SokurenkoWendy E Thomas
Mar 5, 2009·Journal of Medicinal Food·Paola A Pinzón-ArangoTerri A Camesano
Jul 18, 2009·Nature Reviews. Microbiology·Michael Otto
Dec 22, 2009·Integrative Biology : Quantitative Biosciences From Nano to Macro·Claire Verbelen, Yves F Dufrêne
Mar 12, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Andrew W BuckSteven K Lower
Jun 23, 2010·Molecular Nutrition & Food Research·Yatao LiuTerri A Camesano
Nov 4, 2010·Biophysical Journal·Steven K LowerVance G Fowler
May 6, 2011·The Journal of Biological Chemistry·Vannakambadi K GaneshMagnus Höök
Oct 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Steven K LowerVance G Fowler
Nov 18, 2011·Science Translational Medicine·Corinne K CusumanoScott J Hultgren
Dec 25, 2012·Nanoscale·Sofiane El-Kirat-ChatelYves F Dufrêne
Mar 28, 2013·ACS Nano·Prachi TripathiYves F Dufrêne
Jun 27, 2013·Virulence·Anne Marie Krachler, Kim Orth
Oct 12, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Philippe HermanYves F Dufrêne
Dec 18, 2013·Nature Reviews. Microbiology·Timothy J FosterMagnus Höök
Jun 6, 2014·Molecular Microbiology·Philippe HermanYves F Dufrêne
Nov 6, 2014·Nature Reviews. Molecular Cell Biology·Janna K MouwValerie M Weaver
Feb 12, 2015·ACS Nano·Ruby May A SullanYves F Dufrêne
Mar 31, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Thomas VanzieleghemJacques Mahillon
Apr 9, 2015·Nature Reviews. Microbiology·Ana L Flores-MirelesScott J Hultgren
Oct 21, 2015·Molecular Microbiology·Philippe Herman-Bausier, Yves F Dufrêne
Dec 31, 2015·Proceedings of the National Academy of Sciences of the United States of America·Cécile Formosa-DagueYves F Dufrêne
Feb 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Daniel J EchelmanJulio M Fernández
Sep 9, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T J Foster
Oct 8, 2016·Frontiers in Microbiology·Jeffrey P Hymes, Todd R Klaenhammer
Oct 27, 2016·Nature Microbiology·Jie Xiao, Yves F Dufrêne

❮ Previous
Next ❯

Citations

Aug 31, 2020·MicrobiologyOpen·Hawzeen S KhalilJack C Leo
Dec 17, 2020·Frontiers in Microbiology·Michael A JärvåRonnie P-A Berntsson

❮ Previous
Next ❯

Methods Mentioned

BETA
force measurement
AFM
atomic force microscopy

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Current Topics in Microbiology and Immunology
Contributions to Microbiology
Susanne R Talay
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
J R Johnson
International Journal of Medical Microbiology : IJMM
Per Klemm, Mark A Schembri
© 2021 Meta ULC. All rights reserved