Binge drinking is associated with differences in weekday and weekend adherence in HIV-infected individuals

Drug and Alcohol Dependence
Raquel B De BoniRobert Gross

Abstract

Understanding patterns of antiretroviral adherence and its predictors is important for designing tailored interventions. Alcohol use is associated with non-adherence. This study aimed to evaluate: (1) if there was a difference in weekday compared with weekend adherence in HIV-infected individuals from low and middle income countries (LMIC), and (2) whether binge drinking was associated with this difference. Data from a randomized trial conducted at 9 sites in 8 LMIC were analyzed. Microelectronic monitors were used to measure adherence. Differences between weekday and weekend adherence in each quarter (successive 12-week periods) were compared using Wilcoxon signed rank tests and predictors of adherence, including baseline binge drinking, were evaluated using Generalized Estimating Equations. Data from 255 participants were analyzed: 49.8% were male, median age was 37 years and 28.6% enrolled in Haiti. At study entry, only 2.7% reported illicit substance use, but 22.3% reported binge drinking at least once in the 30 days prior to enrollment. Adherence was higher on weekdays than weekends (median percent doses taken: 96.0% vs 94.4%; 93.7% vs 91.7%; 92.6% vs 89.7% and 93.7% vs 89.7% in quarters 1-4 respectively, all p<0.001). Bin...Continue Reading

References

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Citations

Mar 16, 2018·PloS One·Raquel B De BoniUNKNOWN for CCASAnet
Dec 15, 2018·Journal of the International AIDS Society·Marcellin N NouamanUNKNOWN IeDEA
Sep 7, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Timothy H HoltzUNKNOWN Thai HPTN 067/ADAPT Study Team
Aug 21, 2018·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Sarah S DermodyChristian S Hendershot

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