PMID: 8947317Nov 1, 1996Paper

Binge ethanol-induced brain damage in rats: effect of inhibitors of nitric oxide synthase

Alcoholism, Clinical and Experimental Research
J Y ZouM A Collins

Abstract

Testing the possible role of endogenous nitric oxide (NO) in the neurotoxicity of ethanol, we examined how two different NO synthase (NOS) inhibitors affected the extent cerebrocortical and olfactory neuronal damage in a modified "binge intoxication" rat model (Collins et al., Alcohol Clin. Exp. Res. 20:284-292, 1996). Male rats intragastrically fed ethanol (6.5 to 12 g/kg/day) in nutrient solution three times daily for 4 days also received NG-nitro-L-arginine methyl ester by chronic intracerebroventricular infusion or 7-nitro-indazole by daily intraperitoneal injection; control rats were given nutrient solution only and/or vehicles. Blood ethanol levels did not differ among the ethanol-treated groups. The amount of ethanol-dependent neuronal degeneration in the entorihinal cortex, dentate gyrus, and olfactory bulb glomeruli--visualized with the de Olmos cupric silver stain and quantitatively assessed in the binge-intoxicated rats--was either unchanged or significantly increased by the NOS inhibitors. Although the efficacies of the inhibitors cannot be directly compared because of various NOS forms were probably inhibited to differing extents, the results do not support the idea that endogenous NO is a neurotoxic mediator of et...Continue Reading

References

Jan 1, 1992·Neuroscience·S R Vincent, H Kimura
Nov 24, 1992·European Journal of Pharmacology·M G Persson, L E Gustafsson
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B T HopeS R Vincent
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T M DawsonS H Snyder
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Nov 21, 1994·Neuroreport·A MülschS P Olesen
Jan 1, 1994·Progress in Brain Research·T M DawsonS H Snyder
Feb 1, 1995·Alcoholism, Clinical and Experimental Research·M L AdamsT J Cicero
Sep 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Q WangR F Albrecht
Sep 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J HamadaM Reivich
Jan 1, 1995·Life Sciences·M G HollingsheadM R Grever
Jun 1, 1995·Metabolic Brain Disease·F E Lancaster
May 28, 1993·Annals of the New York Academy of Sciences·R C Switzer
Nov 17, 1994·Annals of the New York Academy of Sciences·D A WinkJ B Mitchell
Jan 6, 1995·Biochemical Pharmacology·S C Bondy, S X Guo
Mar 1, 1995·The American Journal of Psychiatry·G TsaiJ T Coyle
Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F ZhangC Iadecola
Apr 1, 1993·Neuroreport·S K Shirazi, J G Wood

❮ Previous
Next ❯

Citations

Nov 5, 2005·Brain Research. Brain Research Reviews·Randall L Davis, Peter J Syapin
Aug 15, 2002·Pharmacology, Biochemistry, and Behavior·Jennifer A ObernierFulton T Crews
Sep 18, 2002·Brain Research. Developmental Brain Research·Daniel J BonthiusNicholas J Pantazis
Oct 17, 1998·Progress in Neurobiology·F Fadda, Z L Rossetti
Feb 13, 2009·Psychological Bulletin·Kelly E Courtney, John Polich
Mar 24, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jean-Christophe CasselRolf Jackisch
Jul 30, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marisa RobertoGeorge R Siggins
Oct 27, 2011·Addiction Biology·Alexander KuzminGeorgy Bakalkin
Oct 8, 1999·Alcoholism, Clinical and Experimental Research·M J DruseJ L Eriksen
Feb 24, 2016·Frontiers in Molecular Neuroscience·Michael A Collins, Edward J Neafsey
Mar 11, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Haseeb Ahmad Khan
Sep 21, 2010·Neurobiology of Learning and Memory·Andrea CippitelliMarkus Heilig
Apr 29, 2004·Alcoholism, Clinical and Experimental Research·Fulton T CrewsAntonio Noronha
Oct 28, 2006·Alcoholism, Clinical and Experimental Research·Fulton CrewsJian Zou
Mar 28, 2007·Alcoholism, Clinical and Experimental Research·Somsak MitrirattanakulIgor Spigelman
Aug 26, 2006·Pharmacology, Biochemistry, and Behavior·Mark A Prendergast, Hilary J Little
May 1, 2001·Alcoholism, Clinical and Experimental Research·C L ShihT N Lin
May 1, 2002·Alcoholism, Clinical and Experimental Research·J A ObernierF T Crews
Oct 23, 2001·American Journal of Physiology. Heart and Circulatory Physiology·H SunW G Mayhan
Dec 25, 2004·Experimental Biology and Medicine·M E JungJ W Simpkins
Feb 24, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M A CollinsE J Neafsey
Dec 29, 2020·Frontiers in Systems Neuroscience·Tanuja Bordia, Natalie M Zahr
May 1, 2021·Brain Sciences·Natalie N NawarawongKimberly Nixon
Jul 23, 2011·Progress in Neurobiology·John W Wright, Joseph W Harding

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.