Binocular response modulation in the lateral geniculate nucleus

The Journal of Comparative Neurology
Kacie DoughertyAlexander Maier

Abstract

The dorsal lateral geniculate nucleus of the thalamus (LGN) receives the main outputs of both eyes and relays those signals to the visual cortex. Each retina projects to separate layers of the LGN so that each LGN neuron is innervated by a single eye. In line with this anatomical separation, visual responses of almost all of LGN neurons are driven by one eye only. Nonetheless, many LGN neurons are sensitive to what is shown to the other eye as their visual responses differ when both eyes are stimulated compared to when the driving eye is stimulated in isolation. This, predominantly suppressive, binocular modulation of LGN responses might suggest that the LGN is the first location in the primary visual pathway where the outputs from the two eyes interact. Indeed, the LGN features several anatomical structures that would allow for LGN neurons responding to one eye to modulate neurons that respond to the other eye. However, it is also possible that binocular response modulation in the LGN arises indirectly as the LGN also receives input from binocular visual structures. Here we review the extant literature on the effects of binocular stimulation on LGN spiking responses, highlighting findings from cats and primates, and evaluate t...Continue Reading

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Citations

Nov 24, 2019·Scientific Reports·Jörgen RosénFredrik Åhs
Oct 18, 2019·Journal of Vision·Michele A CoxAlexander Maier
Oct 10, 2020·Attention, Perception & Psychophysics·Alexander Maier, Naotsugu Tsuchiya
Apr 24, 2021·Frontiers in Aging Neuroscience·Mengling YouDan Ji

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