Binocular Visual Responses in the Primate Lateral Geniculate Nucleus

Current Biology : CB
Natalie ZeaterPaul R Martin

Abstract

The dorsal lateral geniculate nucleus (dLGN) in carnivores and primates is a laminated structure, where each layer gets visual input from only one eye [1, 2]. By contrast, in rodents such as mice and rats, the dLGN is not overtly laminated, the retinal terminals from the two eyes are only partially segregated [3, 4], and many cells in the binocular segment of dLGN get excitatory inputs from both eyes [5, 6]. Here, we show that the evolutionary ancient koniocellular (K) division of primate dLGN, like rodent dLGN, forms a subcortical site of binocular integration. We recorded single-cell activity in dLGN of anesthetized marmoset monkeys. As expected, cells in the parvocellular (P) and magnocellular (M) layers received monocular excitatory inputs. By contrast, many cells in the K layers received excitatory inputs from both eyes. The specialized properties of distinct K sub-populations (for example, blue-yellow color selectivity) were preserved across the two eye inputs, and where tested, the contrast sensitivity of each eye input was roughly matched. The results argue that evolutionarily widely separated orders such as rodents and primates have a shared strategy of integrating signals from the two eyes in subcortical circuits.

References

Dec 1, 1978·The Journal of Comparative Neurology·J H KaasJ K Harting
Jan 1, 1986·Vision Research·P O Bishop, J D Pettigrew
Jan 1, 1987·Experimental Brain Research·J T XueR D Freeman
Aug 1, 1966·The Journal of Physiology·K I Naka, W A Rushton
Jul 1, 1994·Trends in Neurosciences·V A Casagrande
Aug 29, 2003·Journal of Neurophysiology·Matthew S Grubb, Ian D Thompson
Sep 21, 2004·Nature Neuroscience·Lawrence C SincichJonathan C Horton
May 21, 2005·The Journal of Physiology·Kenneth L Grieve
Oct 14, 2005·Progress in Brain Research·Paul D R Gamlin
Jan 13, 2006·Vision Research·Robert A Frazor, Wilson S Geisler
Oct 13, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Edward GrubergSusan Udin
Dec 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Brett A SzmajdaPaul R Martin
Jan 12, 2007·Cerebral Cortex·V A CasagrandeY Ding
Apr 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chris TailbyPeter Lennie
Jun 13, 2012·The Journal of Physiology·Chris TailbyPaul R Martin
Jul 21, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin SchollNicholas J Priebe
Mar 12, 2013·Nature Neuroscience·Shreesh P Mysore, Eric I Knudsen
Mar 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Denise M PiscopoCristopher M Niell
Apr 19, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Soon Keen CheongPaul R Martin
Aug 2, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xinyu ZhaoJianhua Cang
May 27, 2014·Current Biology : CB·Michael HowarthTimothy M Brown

❮ Previous
Next ❯

Citations

Jan 27, 2016·Current Biology : CB·Damian J WallaceJason N D Kerr
Mar 15, 2016·Nature Neuroscience·Cyrille RossantKenneth D Harris
Jun 9, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sid HenriksenBruce Cumming
Nov 17, 2017·Proceedings. Biological Sciences·Jiawei ZhouRobert F Hess
Jan 10, 2018·The Journal of Comparative Neurology·Natalie ZeaterPaul R Martin
Feb 24, 2018·The Journal of Comparative Neurology·Kacie DoughertyAlexander Maier
Aug 5, 2017·Annual Review of Neuroscience·Tania A SeabrookAndrew D Huberman
Nov 14, 2019·Visual Neuroscience·Elissa BellucciniPaul R Martin
Jan 17, 2020·The Journal of Physiology·Brandon MunnPulin Gong
Nov 24, 2019·Scientific Reports·Jörgen RosénFredrik Åhs
Sep 17, 2020·Annual Review of Vision Science·Liang Liang, Chinfei Chen
Oct 3, 2017·Visual Neuroscience·Elizabeth Y Litvina, Chinfei Chen
Jun 19, 2019·Proceedings of the National Academy of Sciences of the United States of America·Milena KaestnerAlex R Wade
Apr 13, 2021·Journal of Neural Engineering·Brianna Thielen, Ellis Meng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Brett A SzmajdaPaul R Martin
Proceedings of the National Academy of Sciences of the United States of America
E Kaplan, R M Shapley
© 2022 Meta ULC. All rights reserved